Single-Cell Transcriptomics Reveals the Molecular Anatomy of Sheep Hair Follicle Heterogeneity and Wool Curvature

December 2021 in “ Frontiers in cell and developmental biology ”

Shanhe Wang, Tianyi Wu, Jing Sun, Yue Li, Zehu Yuan, Wei Sun

single-cell RNA sequencing scRNA-seq hair follicle development wool curvature single-cell suspensions gene expression profiles pseudotime ordering analysis matrix cell lineage hair shaft inner root sheath cells intercellular communication CellChat ligand-receptor pairs signaling pathways differentially expressed genes hair follicle biology

Studysummary This study used single-cell RNA sequencing to map the cellular composition of sheep hair follicles, revealing differentiation pathways and potential molecular mechanisms for wool curvature, which may inform sheep breeding.

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