A Replication Study Confirmed the EDAR Gene to Be a Major Contributor to Population Differentiation Regarding Head Hair Thickness in Asia

    August 2008 in “ Human genetics ”
    Akihiro Fujimoto, Jun Ohashi, Nao Nishida, Taku Miyagawa, Yasuyuki Morishita, Tatsuhiko Tsunoda, Ryosuke Kimura, Katsushi Tokunaga
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    Studysummary This study found that the EDAR 1540T/C genetic variant is significantly associated with hair thickness variation in Japanese populations, enhancing previously observed associations in Southeast Asian groups.
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    In a study examining the genetic basis of hair thickness variation among Asian populations, researchers found that a single nucleotide polymorphism (SNP) in the ectodysplasin A receptor gene (EDAR 1540T/C) was significantly associated with hair fiber thickness in a Japanese population, confirming previous findings in Thai-Mai and Indonesian groups. The association was highly significant (P = 2.7 × 10−6) in the Japanese sample and even stronger (P = 3.8 × 10−10) when data from all three populations were combined, surpassing the influence of age, sex, and population differences. These results suggest that the EDAR gene plays a major role in determining hair thickness among various Asian populations.
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