TLDR The article concludes that the wool follicle is a valuable model for studying tissue interactions and has potential for genetic improvements in wool production.
The 2006 review article explores the biology of the wool follicle, highlighting its significance as a model for tissue interaction research and its economic relevance to the wool industry. It discusses the molecular controls of tissue interaction, the impact of photoperiod and nutrition on growth, and the potential for genetic advancements in wool production. The article reviews findings on the relationship between follicle density and fiber diameter, the importance of the Wnt signaling pathway in follicle development, and breeding strategies for finer wool. It also examines the role of stem cells in new fiber formation, the genetic and nutritional factors affecting wool quality, and the influence of stress and dietary deficiencies on wool growth. The potential for selective breeding to improve husbandry and the use of growth factors for wool harvesting are considered. Additionally, the document addresses the challenges and outcomes of genetic engineering in sheep, the pigmentation of wool, and the need for further research in follicle morphogenesis and hair growth control.
Cited in this study
10 / 10 results
128 citations
,
March 2006 in “American Journal of Pathology” Prolactin contributes to hair loss by promoting hair follicle shrinkage and cell death.
550 citations
,
December 2005 in “The Journal of clinical investigation/The journal of clinical investigation” Researchers successfully isolated and identified key markers of stem cell-enriched human hair follicle bulge cells.
60 citations
,
October 2005 in “Experimental Dermatology” Zinc can both inhibit and stimulate mouse hair growth, and might help recover hair after chemotherapy.
27 citations
,
June 2005 in “The journal of investigative dermatology/Journal of investigative dermatology” The study found that variations in hair protein genes are likely due to evolutionary deletions or duplications.
479 citations
,
January 2005 in “BioEssays” Hair follicle development is controlled by interactions between skin tissues and specific molecular signals.
48 citations
,
December 2004 in “Differentiation” Tooth papilla cells can help regenerate hair follicles and grow hair.
91 citations
,
May 2003 in “American Journal of Pathology” Prolactin affects hair growth cycles and can cause early hair follicle regression.
50 citations
,
August 1999 in “Experimental dermatology” The control system for hair growth cycles is not well understood and needs more research.
20 citations
,
January 1995 in “Cells tissues organs” Changing light periods synchronized wool growth cycles in sheep.
116 citations
,
April 1986 in “The journal of cell biology/The Journal of cell biology” Trichohyalin is a protein in hair follicles that helps form hair filaments.
