Expression Profile Analysis of MicroRNAs During Hair Follicle Development in the Sheep Fetus

June 2019 in “ Bioscience, biotechnology, and biochemistry ”

Han-Yu-Lu Yang, Hua Yang, Shi Guo-qing, Min Shen, Jiahao Yang, Yonglin Yang, Xiaojun Liu

microRNAs miRNAs hair follicle development sheep foetus high-throughput sequencing bioinformatics qRT-PCR secondary hair follicle prolactin signalling pathway platelet activation SF

TLDR Ten miRNAs may play key roles in starting secondary hair follicle development in sheep foetuses.

The study analyzed the expression profiles of miRNAs during 11 developmental periods in sheep foetus skin using high-throughput sequencing and bioinformatics. It identified 72 conserved, 44 novel, and 32 known miRNAs with significant differential expression. qRT-PCR results for 18 miRNAs matched the sequencing data. The 85th day of foetal development marked the start of secondary hair follicle (SF) development, with the prolactin signalling pathway and platelet activation being crucial. Ten miRNAs were identified as potential candidates in SF initiation.

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