Expression Profile Analysis of MicroRNAs During Hair Follicle Development in the Sheep Fetus

April 2019 in “ Bioscience, biotechnology, and biochemistry ”

Han-Yu-Lu Yang, Hua Yang, Shi Guo-qing, Min Shen, Jiahao Yang, Yonglin Yang, Xiaojun Liu

microRNAs miRNAs hair follicle development sheep foetus high-throughput sequencing bioinformatics qRT-PCR secondary hair follicle prolactin signalling pathway platelet activation SF

TLDR Ten miRNAs may play key roles in starting secondary hair follicle development in sheep foetuses.

The study analyzed the expression profiles of microRNAs (miRNAs) during hair follicle development in sheep fetuses, identifying differentially expressed miRNAs at critical developmental stages (75-85 days). Researchers found that secondary hair follicle (SF) development began at 85 days, with significant roles for the prolactin signaling pathway and platelet activation. Key miRNAs such as oar-miR-133 and miR-504 were linked to these pathways. The findings provided insights into the molecular mechanisms of hair follicle development, which could improve wool quality in sheep. Validation through qRT-PCR confirmed the sequencing data for 18 miRNAs.

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