Gene Network Analysis Reveals Candidate Genes Related to Hair Follicle Development in Sheep

February 2022 in “ Research Square (Research Square) ”

Junmin He, Bingru Zhao, Xixia Huang, Xuefeng Fu, Guifen Liu, Yuezhen Tian, Cuiling Wu, Jingyi Mao, Jing Liu, Shuangbao Gun, Kechuan Tian

hair follicle development differentially expressed genes LAMA5 WNT10A BMP7 hair follicle morphogenesis alopecia areata hair loss alopecia

TLDR Key genes influencing sheep hair follicle development were identified, aiding wool breeding and understanding human hair conditions.

The study analyzed mRNA data from 18 Merino sheep to identify genes related to hair follicle development, revealing 7879 differentially expressed genes (DEGs) and 12623 novel-DEGs across six developmental stages. Key genes such as LAMA5, WNT10A, and BMP7 were identified as influential in hair follicle morphogenesis. The findings provided insights into the molecular basis of hair follicle development, offering a foundation for improving sheep wool breeding and potential clues for understanding human hair development and conditions like hair loss and alopecia areata.

View this study on researchsquare.com →

Discuss this study in the Community →

Research cited in this study

13 / 13 results

research TMT-Based Quantitative Proteomic Analysis Reveals the Effect of Bone Marrow Derived Mesenchymal Stem Cells on Hair Follicle Regeneration

4 citations , June 2021 in “Frontiers in Pharmacology”

Bone marrow stem cells and their medium help hair regrowth.

research Mesenchymal Stem Cells Antagonize IFN-Induced Proinflammatory Changes and Growth Inhibition Effects via Wnt/β-Catenin and JAK/STAT Pathway in Human Outer Root Sheath Cells and Hair Follicles

14 citations , April 2021 in “International journal of molecular sciences”

Mesenchymal stem cells may help treat hair loss by improving hair cell growth and reducing inflammation.

research Using WGCNA to Identify Hub Genes of Skin Hair Follicle Development in Fetal Stage of Inner Mongolia Cashmere Goat

16 citations , December 2020 in “PloS one”

Researchers found WNT10A to be a key gene in developing goat hair follicles.

research Azelaic Acid Stimulates Catalase Activation and Promotes Hair Growth Through Upregulation of Gli1 and Gli2 mRNA and Shh Protein

1 citations , October 2020 in “PubMed”

Azelaic acid helps protect hair cells from UV damage and encourages hair growth by increasing certain gene expressions and proteins.

research Deriving Keratinocyte Progenitor Cells and Keratinocytes from Human-Induced Pluripotent Stem Cells

10 citations , August 2020 in “Current protocols in stem cell biology”

Scientists developed a way to create skin and hair cells from human stem cells, which could help treat burns and restore hair.

research PI3K/Akt Signaling Pathway Is Essential for De Novo Hair Follicle Regeneration

30 citations , April 2020 in “Stem Cell Research & Therapy”

PI3K/Akt pathway is crucial for hair growth and regeneration.

Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development

research Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development

136 citations , May 2019 in “Cells”

Stem cell therapy, particularly using certain types of cells, shows promise for treating hair loss by stimulating hair growth and development, but more extensive trials are needed to confirm these findings.

research Expression of Vimentin in Hair Follicle Growth Cycle of Inner Mongolian Cashmere Goats

23 citations , January 2018 in “BMC genomics”

Vimentin is involved in regulating the hair growth cycle in Inner Mongolian Cashmere goats.

research Hairless Up-Regulates TGF-β2 Expression via Down-Regulation of miR-31 in the Skin of Hairpoor (HrHp) Mice

11 citations , January 2015 in “Journal of cellular physiology”

HR protein causes abnormal hair cycles by increasing Tgf-β2 and reducing miR-31.

research Sostdc1 Defines the Size and Number of Skin Appendage Placodes

56 citations , February 2012 in “Developmental biology”

Sostdc1 controls the size and number of hair and mammary gland structures.

research Self-Organizing and Stochastic Behaviors During the Regeneration of Hair Stem Cells

176 citations , April 2011 in “Science”

Hair stem cell regeneration is controlled by signals that can explain different hair growth patterns and baldness.

research TGF-β2 Is Specifically Expressed in Human Dermal Papilla Cells and Modulates Hair Folliculogenesis

43 citations , March 2009 in “Journal of Cellular and Molecular Medicine”

TGF-β2 plays a key role in human hair growth and development.

research BMP Signaling in the Control of Skin Development and Hair Follicle Growth

165 citations , December 2004 in “Differentiation”

BMP signaling is crucial for skin and hair growth.

Related Research

5 / 5 results

research Single-Cell Sequencing Reveals the New Existence Form of Dermal Papilla Cells in the Hair Follicle Regeneration of Cashmere Goats

2 citations , February 2022 in “Genomics”

Researchers discovered new cell types in goat hair follicles that could help understand hair regrowth and human hair loss.

research Shedding Light on Cashmere Goat Hair Follicle Biology: From Morphology Analyses to Transcriptomic Landscape

8 citations , July 2020 in “BMC genomics”

The research found genes that change during cashmere goat hair growth and could help determine the best time to harvest cashmere.

research Hair Follicle Transcriptome Profiles During the Transition from Anagen to Catagen in Cashmere Goat (Capra Hircus)

14 citations , January 2015 in “Genetics and molecular research”

The transition from growth to regression in Cashmere goat hair follicles involves changes in expression of genes related to keratin and cell differentiation.

research Exploring Differentially Expressed Genes by RNA-Seq in Cashmere Goat Skin During Hair Follicle Development and Cycling

61 citations , April 2013 in “PloS one”

The study found key genes and pathways involved in cashmere goat hair growth stages.

research Hoxc13/β-Catenin Correlation with Hair Follicle Activity in Cashmere Goat

22 citations , July 2012 in “Journal of integrative agriculture/Journal of Integrative Agriculture”

Hoxc13 is linked to seasonal hair growth in Cashmere goats and is affected by melatonin.