Hairless Up-Regulates TGF-β2 Expression via Down-Regulation of miR-31 in the Skin of Hairpoor (HrHp) Mice

    January 2015 in “ Journal of cellular physiology ”
    Bong-Kyu Kim, Sungjoo Kim Yoon
    Studysummary This study suggests that abnormal hair cycles in Hr mutant mice may be caused by HR protein overexpression, which down-regulates miR-31 and increases Tgf-β2 expression.
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    Research cited in this study 13

    1. Hairless Down-Regulates Expression of Msx2 and Its Related Target Genes in Hair Follicles Journal of dermatological science · 2013
    2. Hairless Plays a Role in Formation of Inner Root Sheath via Regulation of Dlx3 Gene Journal of biological chemistry/˜The œJournal of biological chemistry · 2012
    3. Paracrine TGF-β Signaling Counterbalances BMP-Mediated Repression in Hair Follicle Stem Cell Activation Cell stem cell · 2012
    4. Micro-RNA-31 Controls Hair Cycle-Associated Changes in Gene Expression Programs of the Skin and Hair Follicle ˜The œFASEB journal · 2010
    5. Molecular Basis for Hair Loss in Mice Carrying a Novel Nonsense Mutation (Hr^rh-R) in the Hairless Gene (Hr) Veterinary pathology · 2010
    6. A Novel Mutation in Hr Causes Abnormal Hair Follicle Morphogenesis in Hairpoor Mouse, an Animal Model for Marie Unna Hereditary Hypotrichosis Mammalian genome · 2009
    7. Loss-Of-Function Mutations of an Inhibitory Upstream ORF in the Human Hairless Transcript Cause Marie Unna Hereditary Hypotrichosis Nature Genetics · 2009
    8. A Novel Missense Mutation in the Mouse Hairless Gene Causes Irreversible Hair Loss: Genetic and Molecular Analyses of Hrm1Enu Genomics · 2006
    9. Keratins of the Human Hair Follicle International review of cytology · 2005
    10. Physical And Functional Interaction Between The Vitamin D Receptor And Hairless Corepressor, Two Proteins Required For Hair Cycling Journal of Biological Chemistry · 2003
    11. The Hairless Gene of the Mouse: Relationship of Phenotypic Effects with Expression Profile and Genotype Developmental Dynamics · 1999
    12. Analysis of Apoptotic Cell Death in Human Hair Follicles In Vivo and In Vitro Journal of Investigative Dermatology · 1998
    13. The Secret Life of the Hair Follicle Trends in genetics · 1992

    Related research 4

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    2. Expression of Matrix Metalloproteinases and Tissue Inhibitor of Matrix Metalloproteinases in the Hair Cycle Experimental and Therapeutic Medicine · 2016
    3. Hair Cycle Resting Phase Is Regulated by Cyclic Epithelial FGF18 Signaling Journal of Investigative Dermatology · 2012
    4. Hair Follicle Expression of 1,25-Dihydroxyvitamin D3 Receptors During the Murine Hair Cycle British Journal of Dermatology · 2006