Hairless Up-Regulates TGF-β2 Expression via Down-Regulation of miR-31 in the Skin of Hairpoor (HrHp) Mice

January 2015 in “ Journal of cellular physiology ”

Bong-Kyu Kim, Sungjoo Kim Yoon

Hairless gene Tgf-β2 miR-31 alopecia hair loss Hr^Hp mice genetic interactions molecular interactions Hairless TGF-beta 2 microRNA-31 baldness

TLDR HR protein causes abnormal hair cycles by increasing Tgf-β2 and reducing miR-31.

The study investigated the molecular mechanisms behind hair loss in "Hairpoor" (Hr^Hp) mice, focusing on the role of the Hairless (Hr) gene. Researchers found that the Hairless gene up-regulated the expression of Tgf-β2 by down-regulating miR-31 in the skin of these mice. This regulatory pathway contributed to the hair loss phenotype observed in Hr^Hp mice. The findings provided insights into the genetic and molecular interactions involved in hair growth and loss, potentially informing future therapeutic strategies for conditions like alopecia.

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Research cited in this study

9 / 9 results

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Hairless Up-Regulates TGF-β2 Expression via Down-Regulation of miR-31 in the Skin of Hairpoor (HrHp) Mice

Research cited in this study

research Hairless Down-Regulates Expression of Msx2 and Its Related Target Genes in Hair Follicles

research Hairless Plays a Role in Formation of Inner Root Sheath via Regulation of Dlx3 Gene

research Paracrine TGF-β Signaling Counterbalances BMP-Mediated Repression in Hair Follicle Stem Cell Activation

research Micro-RNA-31 Controls Hair Cycle-Associated Changes in Gene Expression Programs of the Skin and Hair Follicle

research Molecular Basis for Hair Loss in Mice Carrying a Novel Nonsense Mutation (Hr^rh-R) in the Hairless Gene (Hr)

research A Novel Mutation in Hr Causes Abnormal Hair Follicle Morphogenesis in Hairpoor Mouse, an Animal Model for Marie Unna Hereditary Hypotrichosis

research Loss-Of-Function Mutations of an Inhibitory Upstream ORF in the Human Hairless Transcript Cause Marie Unna Hereditary Hypotrichosis

research The Hairless Gene of the Mouse: Relationship of Phenotypic Effects with Expression Profile and Genotype

research The Secret Life of the Hair Follicle

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