Hairless Up-Regulates TGF-β2 Expression via Down-Regulation of miR-31 in the Skin of Hairpoor (HrHp) Mice

January 2015 in “ Journal of cellular physiology ”

Bong-Kyu Kim, Sungjoo Kim Yoon

Hairless gene Tgf-β2 miR-31 alopecia hair loss Hr^Hp mice genetic interactions molecular interactions Hairless TGF-beta 2 microRNA-31 baldness

TLDR HR protein causes abnormal hair cycles by increasing Tgf-β2 and reducing miR-31.

The study investigated the molecular mechanisms behind hair loss in "Hairpoor" (Hr^Hp) mice, focusing on the role of the Hairless (Hr) gene. Researchers found that the Hairless gene up-regulated the expression of Tgf-β2 by down-regulating miR-31 in the skin of these mice. This regulatory pathway contributed to the hair loss phenotype observed in Hr^Hp mice. The findings provided insights into the genetic and molecular interactions involved in hair growth and loss, potentially informing future therapeutic strategies for conditions like alopecia.

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Research cited in this study

13 / 13 results

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Morphogenesis, Growth Cycle, and Molecular Regulation of Hair Follicles

Hairless Up-Regulates TGF-β2 Expression via Down-Regulation of miR-31 in the Skin of Hairpoor (HrHp) Mice

Research cited in this study

research Hairless Down-Regulates Expression of Msx2 and Its Related Target Genes in Hair Follicles

research Hairless Plays a Role in Formation of Inner Root Sheath via Regulation of Dlx3 Gene

research Paracrine TGF-β Signaling Counterbalances BMP-Mediated Repression in Hair Follicle Stem Cell Activation

research Micro-RNA-31 Controls Hair Cycle-Associated Changes in Gene Expression Programs of the Skin and Hair Follicle

research Molecular Basis for Hair Loss in Mice Carrying a Novel Nonsense Mutation (Hr^rh-R) in the Hairless Gene (Hr)

research A Novel Mutation in Hr Causes Abnormal Hair Follicle Morphogenesis in Hairpoor Mouse, an Animal Model for Marie Unna Hereditary Hypotrichosis

research Loss-Of-Function Mutations of an Inhibitory Upstream ORF in the Human Hairless Transcript Cause Marie Unna Hereditary Hypotrichosis

research A Novel Missense Mutation in the Mouse Hairless Gene Causes Irreversible Hair Loss: Genetic and Molecular Analyses of Hrm1Enu

research Keratins of the Human Hair Follicle

research Physical And Functional Interaction Between The Vitamin D Receptor And Hairless Corepressor, Two Proteins Required For Hair Cycling

research The Hairless Gene of the Mouse: Relationship of Phenotypic Effects with Expression Profile and Genotype

research Analysis of Apoptotic Cell Death in Human Hair Follicles In Vivo and In Vitro

research The Secret Life of the Hair Follicle

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