Hairless Down-Regulates Expression of Msx2 and Its Related Target Genes in Hair Follicles

    Bong-Kyu Kim, Sungjoo Kim Yoon
    Studysummary This study found that Hairless protein down-regulates Msx2 expression, affecting hair follicle formation in Hairpoor mice by altering the MSX2 regulatory pathway.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on jdsjournal.com →
    Discuss this study in the Community →

    Research cited in this study 13

    1. Hairless Plays a Role in Formation of Inner Root Sheath via Regulation of Dlx3 Gene Journal of biological chemistry/˜The œJournal of biological chemistry · 2012
    2. A Novel Mutation in Hr Causes Abnormal Hair Follicle Morphogenesis in Hairpoor Mouse, an Animal Model for Marie Unna Hereditary Hypotrichosis Mammalian genome · 2009
    3. Loss-Of-Function Mutations of an Inhibitory Upstream ORF in the Human Hairless Transcript Cause Marie Unna Hereditary Hypotrichosis Nature Genetics · 2009
    4. Genetic Interplays Between Msx2 And Foxn1 Are Required For Notch1 Expression And Hair Shaft Differentiation Developmental Biology · 2008
    5. Phospholipase C-δ1 Is an Essential Molecule Downstream of Foxn1, the Gene Responsible for the Nude Mutation, in Normal Hair Development The FASEB Journal · 2007
    6. Biology of the Hair Follicle: The Basics Seminars in Cutaneous Medicine and Surgery · 2006
    7. A Novel Missense Mutation in the Mouse Hairless Gene Causes Irreversible Hair Loss: Genetic and Molecular Analyses of Hrm1Enu Genomics · 2006
    8. Hairless Triggers Reactivation of Hair Growth by Promoting Wnt Signaling Proceedings of the National Academy of Sciences of the United States of America · 2005
    9. Physical And Functional Interaction Between The Vitamin D Receptor And Hairless Corepressor, Two Proteins Required For Hair Cycling Journal of Biological Chemistry · 2003
    10. Cyclic Alopecia in Msx2 Mutants: Defects in Hair Cycling and Hair Shaft Differentiation Development · 2002
    11. Whn and mHa3 Are Components of the Genetic Hierarchy Controlling Hair Follicle Differentiation Mechanisms of Development · 1999
    12. Multiple Roles for Activated LEF/TCF Transcription Complexes During Hair Follicle Development and Differentiation Development · 1999
    13. The Secret Life of the Hair Follicle Trends in genetics · 1992