TLDR Hairless protein reduces Msx2 gene activity, affecting hair follicle development.
The study investigated the role of Hairless (HR) in regulating the expression of the Msh homeobox 2 (Msx2) gene and its related target genes in hair follicles. Using HrHp/HrHp mutant mice and various molecular techniques, researchers found that HR down-regulated Msx2 expression, which subsequently led to the down-regulation of its target genes, Foxn1 and Lef1, both in vivo and in vitro. This down-regulation by HR explained the abnormal hair follicle formation observed in HrHp/HrHp mice.
Cited in this study
7 / 7 results
17 citations
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May 2012 in “Journal of biological chemistry/The Journal of biological chemistry” Hairless protein affects hair follicle structure by regulating the Dlx3 gene.
21 citations
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June 2009 in “Mammalian genome” A new mutation in the Hr gene causes hair loss in mice, similar to a human hair disorder.
67 citations
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February 2009 in “Developmental Biology” Msx2 and Foxn1 are both crucial for hair growth and health.
181 citations
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January 2009 in “Nature Genetics” Certain mutations in a hair growth-related gene cause a type of genetic hair loss.
224 citations
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March 2006 in “Seminars in Cutaneous Medicine and Surgery” The document concludes that understanding hair follicle biology can lead to better hair loss treatments.
137 citations
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September 2005 in “Proceedings of the National Academy of Sciences of the United States of America” The HR protein helps hair grow by blocking a hair growth inhibitor, aiding in hair follicle regeneration.
745 citations
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February 1992 in “Trends in genetics” Hair follicles create different cell layers and proteins, controlled by various molecules.
