Hairless Down-Regulates Expression of Msx2 and Its Related Target Genes in Hair Follicles

April 2013 in “ Journal of dermatological science ”

Bong-Kyu Kim, Sungjoo Kim Yoon

Hairless Msx2 Foxn1 Lef1 hair follicles HrHp/HrHp mutant mice

TLDR Hairless protein reduces Msx2 gene activity, affecting hair follicle development.

The study investigated the role of Hairless (HR) in regulating the expression of Msx2 and its related target genes in hair follicles. Using HrHp/HrHp mutant mice, the researchers found that HR down-regulated Msx2 expression, which subsequently led to the down-regulation of Msx2 target genes Foxn1 and Lef1, both in vivo and in vitro. This down-regulation by HR explained the abnormal hair follicle formation observed in HrHp/HrHp mice. The findings highlighted the importance of HR in the MSX2 regulatory pathway and its impact on hair follicle morphogenesis.

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Hairless Down-Regulates Expression of Msx2 and Its Related Target Genes in Hair Follicles

Research cited in this study

research Hairless Plays a Role in Formation of Inner Root Sheath via Regulation of Dlx3 Gene

research A Novel Mutation in Hr Causes Abnormal Hair Follicle Morphogenesis in Hairpoor Mouse, an Animal Model for Marie Unna Hereditary Hypotrichosis

research Loss-Of-Function Mutations of an Inhibitory Upstream ORF in the Human Hairless Transcript Cause Marie Unna Hereditary Hypotrichosis

research Genetic Interplays Between Msx2 And Foxn1 Are Required For Notch1 Expression And Hair Shaft Differentiation

research Phospholipase C-δ1 Is an Essential Molecule Downstream of Foxn1, the Gene Responsible for the Nude Mutation, in Normal Hair Development

research Biology of the Hair Follicle: The Basics

research A Novel Missense Mutation in the Mouse Hairless Gene Causes Irreversible Hair Loss: Genetic and Molecular Analyses of Hrm1Enu

research Hairless Triggers Reactivation of Hair Growth by Promoting Wnt Signaling

research Physical And Functional Interaction Between The Vitamin D Receptor And Hairless Corepressor, Two Proteins Required For Hair Cycling

research Cyclic Alopecia in Msx2 Mutants: Defects in Hair Cycling and Hair Shaft Differentiation

research Whn and mHa3 Are Components of the Genetic Hierarchy Controlling Hair Follicle Differentiation

research Multiple Roles for Activated LEF/TCF Transcription Complexes During Hair Follicle Development and Differentiation

research The Secret Life of the Hair Follicle

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