Phospholipase C-δ1 Is an Essential Molecule Downstream of Foxn1, the Gene Responsible for the Nude Mutation, in Normal Hair Development

    October 2007 in “ The FASEB Journal ”
    Yoshikazu Nakamura, Manabu Ichinohe, Masayuki Hirata … Kiyoko Fukami
    Studysummary This study suggests that hairlessness in nude mice may be due to insufficient expression of phospholipase C-δ1, a molecule essential for normal hair development downstream of the Foxn1 gene.
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    Research cited in this study 9

    1. Foxn1 Promotes Keratinocyte Differentiation by Regulating the Activity of Protein Kinase C Differentiation · 2007
    2. Defining BMP Functions in the Hair Follicle by Conditional Ablation of BMP Receptor IA The Journal of Cell Biology · 2003
    3. Phospholipase Cδ1 Is Required for Skin Stem Cell Lineage Commitment The EMBO Journal · 2003
    4. HOXC13 Is Involved in the Regulation of Human Hair Keratin Gene Expression Journal of Biological Chemistry · 2002
    5. Inhibition of BMP Signaling Affects Growth and Differentiation in the Anagen Hair Follicle The EMBO Journal · 2000
    6. Forkhead/Winged-Helix Transcription Factor Whn Regulates Hair Keratin Gene Expression: Molecular Analysis of the Nude Skin Phenotype Developmental Dynamics · 2000
    7. Whn and mHa3 Are Components of the Genetic Hierarchy Controlling Hair Follicle Differentiation Mechanisms of Development · 1999
    8. Multiple Roles for Activated LEF/TCF Transcription Complexes During Hair Follicle Development and Differentiation Development · 1999
    9. Hoxc13 Mutant Mice Lack External Hair Genes & Development · 1998

    Related research 1

    1. The Extraction And Characterization Of Human Nail Keratin Journal of Dermatological Science · 1991