Foxn1 Promotes Keratinocyte Differentiation by Regulating the Activity of Protein Kinase C

May 2007 in “ Differentiation ”

Jian Li, Ruth Baxter, Lorin Weiner, Paul F. Goetinck, Enzo Calautti, Janice L. Brissette

Foxn1 keratinocyte differentiation protein kinase C PKC inhibitors phosphorylated PKC substrates

Studysummary This study suggests that Foxn1 acts as a brake on PKC signaling in keratinocytes, thereby modulating the stages of differentiation by controlling PKC activity. Our plain-language summary of this paper — not a Tressless recommendation.

The study demonstrated that the transcription factor Foxn1 promoted the terminal differentiation of keratinocytes by regulating protein kinase C (PKC) activity. Foxn1 negatively affected PKC, as its absence led to increased levels of total, primed, and activated PKC, while its overproduction decreased phosphorylated PKC substrates. Applying PKC inhibitors to Foxn1-null keratinocytes normalized differentiation defects, indicating that Foxn1 acted as a brake on PKC signaling. This regulation allowed Foxn1 to control the timing of differentiation steps by modulating PKC activity.

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