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GlossaryProtein Kinase C inhibitors (PKC inhibitors)

blockers that prevent enzyme activity affecting cell growth and differentiation

Protein Kinase C (PKC) inhibitors are substances that block the activity of Protein Kinase C, an enzyme involved in various cellular processes such as cell growth, differentiation, and apoptosis. By inhibiting PKC, these blockers can potentially be used to treat conditions like cancer, cardiovascular diseases, and certain skin disorders, including alopecia, where abnormal PKC activity is implicated.

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research PKC Downregulation Upon Rapamycin Treatment Attenuates Mitochondrial Disease

26 citations, December 2020 in “Nature metabolism”

Rapamycin treatment helps with mitochondrial disease by reducing PKC levels.

research Bisindolylmaleimide Protein Kinase C Inhibitors Delay the Decline in DNA Synthesis in Mouse Hair Follicle Organ Cultures

11 citations, January 1997 in “Skin Pharmacology and Physiology”

A certain inhibitor can slow down the decrease in DNA creation in mouse hair follicles, which might help with hair growth.

research Several Selective Protein Kinase C Inhibitors Including Procyanidins Promote Hair Growth

32 citations, January 2000 in “Skin pharmacology and physiology”

Certain substances that block a specific protein help promote hair growth.

research Foxn1 Promotes Keratinocyte Differentiation by Regulating the Activity of Protein Kinase C

26 citations, May 2007 in “Differentiation”

Foxn1 helps skin cells mature by controlling a specific protein's activity.

research Protein Kinase C Is a Key Target for Attenuation of Leigh Syndrome by Rapamycin

5 citations, February 2019 in “bioRxiv (Cold Spring Harbor Laboratory)”

Rapamycin may help treat Leigh syndrome by targeting protein kinase C.

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community Natural Remedies: Polyphenols and Hair Loss

19 upvotes 5 years ago

Natural remedies to treat hair loss, such as polyphenols, apple peel extract, grape seed extract, green tea extract, peppermint oil, pumpkin seed oil, apigenin, Ginkgo biloba, red clover extract, olive leaf extract, Ecklonia Cava and Grateloupia elliptica. In addition, terpenes, carotenoids, and tocopherols were discussed as potential treatments.