Cyclosporin A Promotes Hair Epithelial Cell Proliferation and Modulates Protein Kinase C Expression and Translocation in Hair Epithelial Cells

September 2001 in “ Journal of Investigative Dermatology ”

Tomoya Takahashi, Ayako Kamimura

Cyclosporin A hair epithelial cells epidermal keratinocytes protein kinase C PKC isozymes α isozyme βI isozyme βII isozyme η isozyme CsA PKC

Studysummary This study found that cyclosporin A stimulates growth in cultured murine hair epithelial cells and reduces protein kinase C expression, suggesting that these actions may contribute to its hair-growing effects.

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The study investigated the effects of Cyclosporin A on murine hair epithelial cells and epidermal keratinocytes, finding that it promoted cell growth by 150%-160% and 140% respectively at certain concentrations, but inhibited growth at doses above 3 µg/ml. Cyclosporin A also reduced the expression and translocation of specific protein kinase C (PKC) isozymes, which negatively affect hair growth, suggesting its hair-growing activity might be due to this modulation. The study used primary cultures from 50 neonatal mice, confirming results in multiple experiments, and highlighted the need for further research into PKC isozyme expression in hair cell proliferation.

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