Cyclosporin A Promotes Hair Epithelial Cell Proliferation and Modulates Protein Kinase C Expression and Translocation in Hair Epithelial Cells

The study found that Cyclosporin A (CsA) significantly promoted the growth of murine hair epithelial cells by 150%-160% and epidermal keratinocytes by 140% at doses of 1-1000 ng/ml, but inhibited growth at doses above 3 µg/ml. CsA also reduced the expression and particulate levels of PKC isozymes (α, βI, βII, η) in hair epithelial cells. These findings suggested that CsA's hair-growing effects might be due to its promotion of hair epithelial cell proliferation and the downregulation or inhibition of PKC isozymes' translocation.