Molecular Mechanisms Affecting Development of Animal Fibers and Some Studies on Goats

June 2023 in “ Livestock studies ”

Senem Esin SELÇUK, Özge ÖZMEN, Reyhan ÇOLAK

Studysummary This review highlights the significance of animal fibers, examining the molecular mechanisms influencing hair follicle development and their impact on fiber quality and quantity, with a focus on studies involving Angora and cashmere goats. Our plain-language summary of this paper — not a Tressless recommendation.

This review article examines the molecular mechanisms involved in the development of animal fibers, particularly focusing on Angora and cashmere goats. It outlines the importance of hair follicles in fiber production and the economic significance of these fibers. The article describes the hair follicle morphogenesis and cycle, highlighting the role of signaling pathways such as Wnt, FGF, TNF, BMP, Shh, TGF, and Notch. It also discusses the impact of miRNAs and lncRNAs on hair follicle development and fiber growth. The review emphasizes the need for further research on molecular mechanisms to enhance fiber properties and mentions specific studies that link hair follicle development in young goats to adult fiber quality and analyze gene expression during different hair follicle phases.

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research Identification of Key Pathways and Genes That Regulate Cashmere Development in Cashmere Goats Mediated by Exogenous Melatonin

3 citations , September 2022 in “Frontiers in veterinary science”

This study identified key genes and signaling pathways involved in cashmere goat hair follicle growth cycles, influenced by melatonin implantation, suggesting a basis for further research on melatonin's regulatory mechanism.

research Integrated Analysis of lncRNAs and mRNAs by RNA-Seq in Secondary Hair Follicle Development and Cycling (Anagen, Catagen, and Telogen) of Jiangnan Cashmere Goat (Capra hircus)

24 citations , May 2022 in “BMC Veterinary Research”

This study identified key mRNAs and lncRNAs, along with related pathways, that play potentially important roles in hair follicle development and cycling in cashmere goats.

research Seasonal Gene Expression Profile Responsible for Hair Follicle Development in Angora Goats

2 citations , March 2022 in “Research Square (Research Square)”

In this study, the expression of certain hair follicle-related genes differed between growth phases in Angora goats, with HOXC13 showing overexpression during the anagen phase, potentially influencing the mohair's shine and texture.

research The Fiber Diameter Traits of Tibetan Cashmere Goats Are Governed by the Inherent Differences in Stress, Hypoxic, and Metabolic Adaptations: An Integrative Study of Proteome and Transcriptome

17 citations , March 2022 in “BMC Genomics”

This study found that differences in cashmere fiber diameter in Tibetan cashmere goats are associated with variations in metabolic, hypoxic, and stress response-related proteins, offering insights for breeding strategies.

research Identification of Key Pathways and Genes Related to the Development of Hair Follicle Cycle in Cashmere Goats

59 citations , January 2021 in “Genes”

This study reports identifying 12 candidate genes potentially involved in regulating hair follicle development in cashmere goats, which could contribute to improving cashmere production.

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22 citations , April 2020 in “Scientific reports”

This study explored gene expression in Changthangi goats and found that higher expression of keratin-related genes and specific signaling pathways may play a role in the development of Pashmina fiber.

LncRNA-000133 from Secondary Hair Follicle of Cashmere Goat: Identification, Regulatory Network, and Its Effects on Inductive Property of Dermal Papilla Cells

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18 citations , January 2019 in “Animal Biotechnology”

This study found that lncRNA-000133 may play a role in secondary hair follicle reconstruction and cashmere fiber growth in goats, potentially through its interaction with the methylation of its regulatory region and dermal papilla cells.

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25 citations , October 2018 in “PloS one”

This study explored hair follicle gene expression in Inner Mongolia Cashmere goats and identified potential regulators of the transition between growth phases, including IL17RB and ZNF genes.

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127 citations , March 2016 in “PLoS ONE”

This study found that transcriptome profiling of cashmere goat skin revealed key genes and pathways involved in hair follicle initiation, differentiation, and maturation, which are critical for improving fleece production.

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300 citations , August 2012 in “Seminars in Cell & Developmental Biology”

This review discusses mesenchymal–epithelial interactions in hair follicle development and cycling, highlighting recent insights without reporting new experimental results.

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28 citations , January 2012 in “Biological & pharmaceutical bulletin”

This study found that the protein hairless acts as both a corepressor and coactivator of the vitamin D receptor, influencing gene transcription in a ligand-selective manner.

Towards Dissecting the Pathogenesis of Retinoid-Induced Hair Loss: All-Trans Retinoic Acid Induces Premature Hair Follicle Regression by Upregulation of Transforming Growth Factor-β2 in the Dermal Papilla

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92 citations , June 2005 in “Journal of Investigative Dermatology”

This study found that the retinoid all-trans retinoic acid induced a catagen-like stage in human scalp hair follicles, suggesting upregulation of TGF-beta2 as a contributing mechanism.

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92 citations , February 2005 in “Endocrinology”

This study found that estrogen receptor beta plays a significant role in murine hair growth control, potentially acting as a silencer of estrogen receptor alpha's catagen-promoting effects.

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479 citations , January 2005 in “BioEssays”

This review introduces the morphological and molecular principles of hair follicle development but reports no new experimental results, focusing on recent insights and forming a working hypothesis.

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109 citations , June 2000 in “Development”

This study reports that activating Notch signaling in the hair follicle cortex of transgenic mice caused abnormal differentiation of the medulla and cuticle, highlighting potential cell-cell interactions.

Localization of Members of the Notch System and the Differentiation of Vibrissa Hair Follicles: Receptors, Ligands, and Fringe Modulators

research Localization of Members of the Notch System and the Differentiation of Vibrissa Hair Follicles: Receptors, Ligands, and Fringe Modulators

62 citations , January 2000 in “Developmental dynamics”

This study found that Notch-related genes, including Notch1 and Notch2, and their ligands and regulators, have distinct patterns of expression during mouse hair vibrissa follicle development and the adult hair cycle.

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150 citations , May 1993 in “The journal of cell biology/The Journal of cell biology”

This study suggests that mNotch expression plays a significant role in hair follicle differentiation and cell fate selection within the follicle during development.