The Molecular Anatomy of Cashmere Goat Hair Follicle During Cytodifferentiation Stage
October 2024
in “
BMC Genomics
”
hair follicle cytodifferentiation single-cell RNA sequencing scRNA-seq cortex cuticle inner root sheath medulla morphogenesis transcription factors GATA3 LEF1 PRDM1 autophagy ferroptosis hair follicle development RNA sequencing cell differentiation hair structure gene regulation cell death processes
TLDR Understanding hair follicle development can help improve cashmere quality.
This study provides a detailed molecular analysis of cashmere goat hair follicle development during the cytodifferentiation stage using single-cell RNA sequencing (scRNA-seq). By examining 4,995 cells from Shaanbei white cashmere goats, researchers identified nine distinct cell populations, including cortex/cuticle, inner root sheath, and medulla, which are crucial for hair follicle morphogenesis. The study highlights the roles of transcription factors like GATA3, LEF1, and PRDM1, and processes such as autophagy and ferroptosis in hair follicle development. These findings offer insights into hair follicle morphogenesis and suggest strategies for improving cashmere fiber quality, with implications for breeding programs and the cashmere industry. The study involved three fetuses from three pregnant female goats, ensuring ethical compliance.
