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GlossaryFerroptosis

iron-dependent cell death caused by lipid peroxidation

Ferroptosis is a type of cell death that is distinct from other forms like apoptosis or necrosis. It is characterized by the accumulation of iron and the subsequent production of reactive oxygen species, leading to lipid peroxidation and cell membrane damage. This process is significant in various diseases, including cancer and neurodegeneration, and understanding it can help in developing targeted therapies.

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research Suppression of Uterine and Placental Ferroptosis by N-Acetylcysteine in a Rat Model of Polycystic Ovary Syndrome

53 citations, November 2021 in “Molecular Human Reproduction”

N-acetylcysteine may help treat uterine and placental issues in PCOS.

Induction of Hyperandrogenism and Insulin Resistance Differentially Modulates Ferroptosis in Uterine and Placental Tissues of Pregnant Rats

research Induction of Hyperandrogenism and Insulin Resistance Differentially Modulates Ferroptosis in Uterine and Placental Tissues of Pregnant Rats

2 citations, March 2020 in “bioRxiv (Cold Spring Harbor Laboratory)”

HAIR may cause fetal loss by triggering different cell death processes in the uterus and placenta.

4-Octyl Itaconate Alleviates Cisplatin-Induced Ferroptosis Possibly Via Activating the NRF2/HO-1 Signalling Pathway

research 4-Octyl Itaconate Alleviates Cisplatin-Induced Ferroptosis Possibly Via Activating the NRF2/HO-1 Signalling Pathway

1 citations, March 2024 in “Journal of Cellular and Molecular Medicine”

4-octyl itaconate may prevent hearing loss caused by the drug cisplatin by activating certain cell protection pathways.

Sinapic Acid and Glabridin Synergistically Mitigate Androgenetic Alopecia by Modulating Ferroptosis Through Stabilization of Beta-Catenin Against Ubiquitin-Dependent Degradation

research Sinapic Acid and Glabridin Synergistically Mitigate Androgenetic Alopecia by Modulating Ferroptosis Through Stabilization of Beta-Catenin Against Ubiquitin-Dependent Degradation

July 2025 in “PubMed”

Sinapic acid and glabridin together help hair growth in androgenetic alopecia.

Rapidly Gelling Sprayable Hydrogels Integrating Carbon Quantum Dots and Plant Extracellular Vesicles Enable Multifunctional Wound Care via Photothermal Management, Immunomodulation, and Ferroptosis

research Rapidly Gelling Sprayable Hydrogels Integrating Carbon Quantum Dots and Plant Extracellular Vesicles Enable Multifunctional Wound Care via Photothermal Management, Immunomodulation, and Ferroptosis

July 2025 in “Small”

A new sprayable hydrogel helps heal wounds faster and reduces inflammation.

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