Comparative Proteomic Analyses Using iTRAQ-Labeling Provides Insights Into Fiber Diversity in Sheep and Goats

    October 2017 in “ Journal of proteomics
    Yan Li, Guangxian Zhou, Rui Zhang, Jiazhong Guo, Chao Li, Graeme B. Martin, Yulin Chen, Xiaolong Wang
    TLDR The research found specific proteins that affect fiber characteristics and hair growth in sheep and goats.
    The study used an iTRAQ-based proteomic approach to analyze 27 fiber samples from sheep and goats, identifying proteins that contribute to fiber diversity. Key proteins identified included keratin and keratin-associated proteins, as well as those related to hair growth and fatty acid synthesis. The DSC2 gene was highlighted as a significant determinant of woolly versus straight hair in goats. This research provided a valuable list of candidate proteins for future studies on the molecular mechanisms underlying fiber diversity in fiber-producing animals.
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