Comparative Proteomic Analyses Using iTRAQ-Labeling Provides Insights Into Fiber Diversity in Sheep and Goats

The study used an iTRAQ-based proteomic approach to analyze 27 fiber samples from sheep and goats, identifying proteins that contribute to fiber diversity. Key proteins identified included keratin and keratin-associated proteins, as well as those related to hair growth and fatty acid synthesis. The DSC2 gene was highlighted as a significant determinant of woolly versus straight hair in goats. This research provided a valuable list of candidate proteins for future studies on the molecular mechanisms underlying fiber diversity in fiber-producing animals.