TLDR Key proteins and pathways are crucial for wool fineness, but more research is needed.
The study on Gansu alpine fine-wool sheep used Astral-DIA proteomics technology to identify 67 differentially expressed proteins related to wool fineness, analyzing wool tissues from 8 sheep. Key proteins such as KRT26, KRT71, KRT72, and KRT74, and pathways like glutathione metabolism were found to be crucial for regulating wool characteristics. Although the study provides insights into molecular mechanisms and potential candidate factors for breeding programs, the correlation analysis did not achieve statistical significance for wool fiber diameter, suggesting the need for further research with larger sample sizes.
March 2024 in “International journal of molecular sciences” The research identified key proteins that affect wool fiber thickness in Angora rabbits.
October 2023 in “International journal of molecular sciences” Key proteins and pathways regulate wool fiber diameter in Alpine Merino sheep.
September 2023 in “Animals” Genes linked to wool fineness in sheep have been identified.
Researchers made a mouse model with curly hair and hair loss by editing a gene.
9 citations
,
February 2022 in “Nature communications” Rare changes in the KRT82 gene are linked to a higher risk of Alopecia Areata.
2 citations
,
July 2021 in “Genes” A specific genetic change in the KRT71 gene causes a hair loss condition in Hereford cattle.
26 citations
,
April 2019 in “Genes” lncRNA XLOC_008679 and gene KRT35 affect cashmere fineness in goats.
29 citations
,
October 2017 in “Journal of proteomics” The research found specific proteins that affect fiber characteristics and hair growth in sheep and goats.
27 citations
,
November 2007 in “Genomics” Mutations in specific keratin genes cause improper hair structure in mice due to faulty keratin protein assembly.
