Screening of Proteins Related to Wool Development and Fineness in Gansu Alpine Fine-Wool Sheep

September 2025 in “ Animals ”

Zhaohua He, Liming Tian, Guan Wang, Fangfang Zhao, Pengfei Zhao, Shuhong Zhang, Shaobin Li, Guangli Yang

KRT26 KRT71 KRT72 KRT74 glutathione metabolism

Studysummary In this study, researchers using Astral—DIA proteomics technology identified 67 differentially expressed proteins in Gansu alpine fine-wool sheep, linking proteins like keratin and MGST3 in pathways to wool fineness regulation, particularly highlighting their association with hair follicle development.

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The study on Gansu alpine fine-wool sheep used Astral-DIA proteomics technology to identify 67 differentially expressed proteins related to wool fineness, analyzing wool tissues from 8 sheep. Key proteins such as KRT26, KRT71, KRT72, and KRT74, and pathways like glutathione metabolism were found to be crucial for regulating wool characteristics. Although the study provides insights into molecular mechanisms and potential candidate factors for breeding programs, the correlation analysis did not achieve statistical significance for wool fiber diameter, suggesting the need for further research with larger sample sizes.

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