Deletion of the Epidermis Derived Laminin γ1 Chain Leads to Defects in the Regulation of Late Hair Morphogenesis

May 2016 in “ Matrix Biology ”

Anja Fleger-Weckmann, Yasemin Üstün, Jennifer E. Kloepper, Ralf Paus, Wilhelm Bloch, Zu-Lin Chen, Jeannine Wegner, Lydia Sorokin, Lutz Langbein, Beate Eckes, Paola Zigrino, Thomas Krieg, Roswitha Nischt

laminin γ1 hair morphogenesis hair follicle keratinocytes laminin-511 laminin-211 dermo-epidermal junction BMP-MSX2-HOXC13-FOXN1 signaling axis

Studysummary In this mouse study, researchers found that the absence of laminin-511 in skin delays hair follicle development and disrupts hair shaft differentiation, affecting key transcription factors for hair keratins.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

This study demonstrated that the epidermal laminin γ1 chain played a crucial role in regulating late hair morphogenesis and differentiation. Mice with a deletion of laminin γ1 in basal keratinocytes (LAMC1EKO) exhibited delayed hair follicle morphogenesis, reduced proliferation of hair matrix cells, and impaired hair shaft differentiation. The absence of keratinocyte-derived laminin-511 and the ectopic deposition of fibroblast-derived laminin-211 in the dermo-epidermal junction contributed to these defects. The study also highlighted the importance of the BMP-MSX2-HOXC13-FOXN1 signaling axis in hair follicle differentiation and proliferation.

View this study on sciencedirect.com →

Discuss this study in the Community →

Research cited in this study

15 / 15 results

research Emerging Interactions Between Skin Stem Cells and Their Niches

426 citations , August 2014 in “Nature Medicine”

This narrative review examines the interactions between skin stem cells and their niches, finding new insights from advancements in genetic and imaging tools but reporting no new experimental results.

research The Nude Mutant Gene Foxn1 Is a HOXC13 Regulatory Target During Hair Follicle and Nail Differentiation

68 citations , December 2010 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study suggests a regulatory model where HOXC13 activates Foxn1, affecting hair and nail differentiation, supported by similarities in Hoxc13(tm1Mrc) and Foxn1(nu) mice phenotypes and gene expression patterns.

research The Hair Follicle as a Dynamic Mini-Organ

759 citations , February 2009 in “Current Biology”

This review summarizes fundamental concepts and recent advancements in hair follicle biology, including insights from mouse models into broader molecular and cellular processes relevant to regeneration and development.

research Genetic Interplays Between Msx2 And Foxn1 Are Required For Notch1 Expression And Hair Shaft Differentiation

67 citations , December 2008 in “Developmental Biology”

This study found that the transcription factors Msx2 and Foxn1 are crucial for maintaining Notch1 expression in the hair follicle matrix, which is necessary for proper hair differentiation.

research Hair Follicle-Specific Keratins And Their Diseases

138 citations , March 2007 in “Experimental cell research”

This review discusses hair keratins and hair follicle-specific epithelial keratins and their association with inherited hair disorders, reporting no new clinical results.

Evidence That the Satin Hair Mutant Gene Foxq1 Is Among Multiple and Functionally Diverse Regulatory Targets for Hoxc13 During Hair Follicle Differentiation

research Evidence That the Satin Hair Mutant Gene Foxq1 Is Among Multiple and Functionally Diverse Regulatory Targets for Hoxc13 During Hair Follicle Differentiation

65 citations , July 2006 in “Journal of biological chemistry/The Journal of biological chemistry”

This study found that overexpression of Hoxc13 in GC13 mouse models affects hair follicle differentiation by interacting with medulla-specific genes, particularly Foxq1, suggesting a regulatory pathway for medulla differentiation.

research Keratins of the Human Hair Follicle

276 citations , January 2005 in “International review of cytology”

More research is needed to understand how hair keratins work and their role in hair disorders.

research Molecular Principles of Hair Follicle Induction and Morphogenesis

479 citations , January 2005 in “BioEssays”

This review introduces the morphological and molecular principles of hair follicle development but reports no new experimental results, focusing on recent insights and forming a working hypothesis.

research α3β1-Integrin Regulates Hair Follicle But Not Interfollicular Morphogenesis in Adult Epidermis

45 citations , May 2003 in “Journal of Cell Science”

This study found that α3β1-integrin is crucial for maintaining normal hair follicle morphology in mice, as its deficiency leads to severe abnormalities despite not affecting interfollicular epidermal differentiation.

research Molecular Mechanisms Regulating Hair Follicle Development

854 citations , February 2002 in “The journal of investigative dermatology/Journal of investigative dermatology”

This review summarizes recent advances in understanding the molecular mechanisms of hair follicle formation and discusses potential future clinical applications for treating hair loss and skin tumors, but it reports no new clinical results.

research Overexpression of Hoxc13 in Differentiating Keratinocytes Results in Downregulation of a Novel Hair Keratin Gene Cluster and Alopecia

114 citations , May 2001 in “Development”

This study found that overexpressing the Hoxc13 gene in mice causes hair loss and a skin condition similar to ichthyosis, identifying several gene targets that may regulate hair growth.

research Inhibition of BMP Signaling Affects Growth and Differentiation in the Anagen Hair Follicle

305 citations , December 2000 in “The EMBO Journal”

Inhibiting Bmp signaling disrupts hair growth and differentiation.

research Multiple Roles for Activated LEF/TCF Transcription Complexes During Hair Follicle Development and Differentiation

990 citations , October 1999 in “Development”

This study found that LEF1/TCF3 is necessary but not sufficient for TOPGAL activation in hair follicle development, indicating complex regulation in the skin.

research Splitting Hairs: Molecular Mechanisms of Hair and Feather Development

158 citations , November 1998 in “Cell”

β-catenin affects hair growth and can lead to tumors, needing more research for better understanding.

research Hoxc13 Mutant Mice Lack External Hair

245 citations , January 1998 in “Genes & Development”

This study found that Hoxc13 mutations in mice cause defects in hair, nail, and tongue structures, with the most noticeable issue being brittle hair leading to alopecia.