Deletion of the Epidermis Derived Laminin γ1 Chain Leads to Defects in the Regulation of Late Hair Morphogenesis

May 2016 in “ Matrix Biology ”

Anja Fleger-Weckmann, Yasemin Üstün, Jennifer E. Kloepper, Ralf Paus, Wilhelm Bloch, Zu-Lin Chen, Jeannine Wegner, Lydia Sorokin, Lutz Langbein, Beate Eckes, Paola Zigrino, Thomas Krieg, Roswitha Nischt

laminin γ1 hair morphogenesis hair follicle keratinocytes laminin-511 laminin-211 dermo-epidermal junction BMP-MSX2-HOXC13-FOXN1 signaling axis

TLDR Deleting a specific protein in skin cells disrupts normal hair growth and development.

This study demonstrated that the epidermal laminin γ1 chain played a crucial role in regulating late hair morphogenesis and differentiation. Mice with a deletion of laminin γ1 in basal keratinocytes (LAMC1EKO) exhibited delayed hair follicle morphogenesis, reduced proliferation of hair matrix cells, and impaired hair shaft differentiation. The absence of keratinocyte-derived laminin-511 and the ectopic deposition of fibroblast-derived laminin-211 in the dermo-epidermal junction contributed to these defects. The study also highlighted the importance of the BMP-MSX2-HOXC13-FOXN1 signaling axis in hair follicle differentiation and proliferation.

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