Deletion of the Epidermis Derived Laminin γ1 Chain Leads to Defects in the Regulation of Late Hair Morphogenesis

    May 2016 in “ Matrix Biology ”
    Anja Fleger-Weckmann, Yasemin Üstün, Jennifer E. Kloepper … Roswitha Nischt
    Studysummary In this mouse study, researchers found that the absence of laminin-511 in skin delays hair follicle development and disrupts hair shaft differentiation, affecting key transcription factors for hair keratins.
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    Research cited in this study 15

    1. Emerging Interactions Between Skin Stem Cells and Their Niches Nature Medicine · 2014
    2. The Nude Mutant Gene Foxn1 Is a HOXC13 Regulatory Target During Hair Follicle and Nail Differentiation ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2010
    3. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009
    4. Genetic Interplays Between Msx2 And Foxn1 Are Required For Notch1 Expression And Hair Shaft Differentiation Developmental Biology · 2008
    5. Hair Follicle-Specific Keratins And Their Diseases Experimental cell research · 2007
    6. Evidence That the Satin Hair Mutant Gene Foxq1 Is Among Multiple and Functionally Diverse Regulatory Targets for Hoxc13 During Hair Follicle Differentiation Journal of biological chemistry/˜The œJournal of biological chemistry · 2006
    7. Keratins of the Human Hair Follicle International review of cytology · 2005
    8. Molecular Principles of Hair Follicle Induction and Morphogenesis BioEssays · 2005
    9. α3β1-Integrin Regulates Hair Follicle But Not Interfollicular Morphogenesis in Adult Epidermis Journal of Cell Science · 2003
    10. Molecular Mechanisms Regulating Hair Follicle Development ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2002
    11. Overexpression of Hoxc13 in Differentiating Keratinocytes Results in Downregulation of a Novel Hair Keratin Gene Cluster and Alopecia Development · 2001
    12. Inhibition of BMP Signaling Affects Growth and Differentiation in the Anagen Hair Follicle The EMBO Journal · 2000
    13. Multiple Roles for Activated LEF/TCF Transcription Complexes During Hair Follicle Development and Differentiation Development · 1999
    14. Splitting Hairs: Molecular Mechanisms of Hair and Feather Development Cell · 1998
    15. Hoxc13 Mutant Mice Lack External Hair Genes & Development · 1998

    Related research 1

    1. Deletion of the Epidermis Derived Laminin γ1 Chain Leads to Defects in the Regulation of Late Hair Morphogenesis Matrix Biology · 2016