The Fiber Diameter Traits of Tibetan Cashmere Goats Are Governed by the Inherent Differences in Stress, Hypoxic, and Metabolic Adaptations: An Integrative Study of Proteome and Transcriptome
March 2022
in “
BMC Genomics
”
TLDR Cashmere fiber diameter in Tibetan goats is influenced by their stress, oxygen, and metabolic adaptations.
The study investigated the genetic and protein differences influencing fiber diameter in Tibetan cashmere goats, adapted to high altitudes. By analyzing proteomic and transcriptomic data from goat skin tissues, researchers identified 1,980 proteins and mapped 1,730 to original protein coding genes. They found 29 differentially expressed proteins (DEPs) between fine and coarse cashmere, linked to processes like oxidation-reduction, cell redox homeostasis, and signaling pathways such as PI3K-Akt, MAPK, and Wnt. Key proteins like GC, VTN, AEBP1, and GPR142 were validated as potential candidate genes for cashmere traits. The study concluded that differences in cashmere fiber diameter were due to inherent metabolic, hypoxic, and stress response adaptations, offering insights for breeding strategies and understanding the genetic mechanisms of cashmere traits.
