Comprehensive Transcriptome and Methylome Analysis Delineates the Biological Basis of Hair Follicle Development and Wool-Related Traits in Merino Sheep

    September 2021 in “ BMC Biology ”
    Bingru Zhao, Hanpeng Luo, Junmin He, Xixia Huang, Siqian Chen, Xuefeng Fu, Weidan Zeng, Yuezhen Tian, Shuli Liu, Congjun Li, George E. Liu, Lingzhao Fang, Shengli Zhang, Kechuan Tian
    TLDR Key genes and factors crucial for hair follicle development and wool traits in Merino sheep were identified.
    This study investigated the molecular mechanisms of hair follicle development in Merino sheep by analyzing transcriptome and methylome data from 18 sheep across six developmental stages. The research identified distinct expression profiles of protein-coding genes, lncRNAs, circRNAs, and miRNAs, and their interactions with DNA methylation, which were crucial for epithelial differentiation and hair follicle morphogenesis. Key transcription factors involved in these processes were identified, and genes upregulated at specific stages, particularly E105, were linked to wool-related traits. The study also found associations between sheep wool trait genes and human dermatological, metabolic, and immune traits, providing insights into hair follicle morphogenesis and potential improvements in sheep breeding for wool traits.
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