Transcriptome Reveals Long Non-Coding RNAs and mRNAs Involved in Primary Wool Follicle Induction in Carpet Sheep Fetal Skin

    May 2018 in “ Frontiers in physiology ”
    Yangfan Nie, Shaomei Li, Xin Zheng, Wenshuo Chen, Xueer Li, Zhiwei Liu, Yong Hu, Haisheng Qiao, Quanqing Qi, Quanbang Pei, Danzhuoma Cai, Mei Yu, Chunyan Mou
    TLDR Certain RNA molecules are important for the development of wool follicles in sheep.
    The study investigated the roles of long non-coding RNAs (lncRNAs) and mRNAs in the induction of primary wool follicles in carpet sheep fetal skin using RNA sequencing. Researchers identified 1,234 lncRNAs and 2,345 mRNAs differentially expressed during wool follicle development, with key pathways such as WNT, BMP, EDAR, and FGF significantly enriched. The findings provided insights into the molecular mechanisms underlying wool follicle induction, suggesting complex regulatory relationships between lncRNAs and mRNAs, and highlighted potential applications for improving wool production and understanding hair growth in other species.
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