Hierarchical Patterning Modes Orchestrate Hair Follicle Morphogenesis

July 2017 in “ PLoS Biology ”

James D. Glover, Kirsty L. Wells, Franziska Matthäus, Kevin J. Painter, William Ho, Jon Riddell, Jeanette A. Johansson, Matthew J. Ford, Colin A.B. Jahoda, Václav Klika, Richard L. Mort, Denis J. Headon

hair follicle morphogenesis Turing reaction-diffusion system mesenchymal self-organisation FGF signalling WNT signalling BMP signalling mesenchymal cell condensation epidermal prepattern TGF β signalling chemotactic patterning

Studysummary This study found that hair follicle patterning in development may arise from a combination of epidermal prepattern signals and mesenchymal self-organisation, with fibroblast growth factor and bone morphogenetic protein activities playing key roles.

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