BMP2 And BMP7 Play Antagonistic Roles In Feather Induction
August 2008
in “
Development
”
TLDR BMP2 and BMP7 have opposite roles in feather formation.
The study revealed that BMP2 and BMP7 played antagonistic roles in feather induction, with BMP7 acting as a chemoattractant to recruit cells into dermal condensations and BMP2 halting cell migration later in the process. Both BMPs were necessary for feather morphogenesis, with BMP7 expressed earlier and BMP2 later. The researchers proposed a reaction-diffusion model to simulate feather patterning and explain the negative effects of excess BMP2 or BMP7 on feather formation.
