The Historical Studies Underpinning the Concept of Hair Follicle Neogenesis

January 2022 in “ Springer eBooks ”

Claire A. Higgins, Colin A.B. Jahoda

hair follicle neogenesis fibroblast growth factors FGFs dermal condensation hair follicle development FGF-2 FGF20 FGF9 epithelial-mesenchymal interactions molecular signaling pathways hair follicle morphogenesis hair follicle regeneration hair follicle creation growth factors skin cell interactions hair growth signaling

Studysummary This review discusses the potential of the hair follicle dermis to direct hair development and explores concepts related to hair growth and androgenetic alopecia, without reporting new clinical results.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

View this study on link.springer.com →

Discuss this study in the Community →

Research cited in this study

52 / 52 results

research A Bald Statement: Current Approaches to Manipulate Miniaturization Focus Only on Promoting Hair Growth

30 citations , May 2018 in “Experimental Dermatology”

This article reviews the cellular dynamics affecting dermal papilla size in androgenetic alopecia and suggests targeting DP size could improve therapies, but it presents no new clinical data.

research Hierarchical Patterning Modes Orchestrate Hair Follicle Morphogenesis

149 citations , July 2017 in “PLoS Biology”

This study found that hair follicle patterning in development may arise from a combination of epidermal prepattern signals and mesenchymal self-organisation, with fibroblast growth factor and bone morphogenetic protein activities playing key roles.

research Methods for the Isolation and 3D Culture of Dermal Papilla Cells from Human Hair Follicles

55 citations , April 2017 in “Experimental Dermatology”

This article details laboratory methods for isolating and culturing human dermal papilla cells but provides no new experimental results.

research Epithelial-Mesenchymal Micro-Niches Govern Stem Cell Lineage Choices

214 citations , April 2017 in “Cell”

This study found that micro-niches within hair follicles create heterogeneity among stem cells and transit-amplifying cells, leading to specialized progenitors that control tissue morphogenesis and regeneration.

Induction of Hair Follicle Dermal Papilla Cell Properties in Human Induced Pluripotent Stem Cell-Derived Multipotent LNGFR(+)THY-1(+) Mesenchymal Cells

research Induction of Hair Follicle Dermal Papilla Cell Properties in Human Induced Pluripotent Stem Cell-Derived Multipotent LNGFR(+)THY-1(+) Mesenchymal Cells

42 citations , February 2017 in “Scientific Reports”

In this study, researchers differentiated induced pluripotent stem cells into cells with dermal papilla-like properties, demonstrating their potential role in hair follicle bioengineering and drug testing for hair growth.

Differential Expression Between Human Dermal Papilla Cells from Balding and Non-Balding Scalps Reveals New Candidate Genes for Androgenetic Alopecia

research Differential Expression Between Human Dermal Papilla Cells from Balding and Non-Balding Scalps Reveals New Candidate Genes for Androgenetic Alopecia

46 citations , April 2016 in “Journal of Investigative Dermatology”

This study suggests that down-regulation of vasculature-related genes in dermal papilla cells from balding scalps might contribute to the development of androgenetic alopecia.

research Fate of Prominin-1 Expressing Dermal Papilla Cells During Homeostasis, Wound Healing, and Wnt Activation

32 citations , August 2015 in “Journal of Investigative Dermatology”

In this study using a mouse model, Prom1+ dermal papilla cells were found to regulate the size of the papilla via β-catenin communication but did not aid in dermal repair.

research An Integrated Transcriptome Atlas of Embryonic Hair Follicle Progenitors, Their Niche, and the Developing Skin

173 citations , August 2015 in “Developmental cell”

This study characterizes gene expression patterns in embryonic hair follicle progenitors and their niche, identifying signaling pathways like axon guidance that may drive cellular rearrangements for hair follicle formation.

research Oxidative Stress-Associated Senescence in Dermal Papilla Cells of Men with Androgenetic Alopecia

93 citations , February 2015 in “Journal of Investigative Dermatology”

This study suggests that oxidative stress may contribute to androgenetic alopecia by inducing premature senescence and secretion of hair growth inhibitors in dermal papilla cells from balding scalp.

research Hair Follicle Dermal Stem Cells Regenerate the Dermal Sheath, Repopulate the Dermal Papilla, and Modulate Hair Type

184 citations , November 2014 in “Developmental Cell”

This study identifies a bipotent stem cell in adult hair follicles that self-renews and contributes to dermal sheath and papilla cell populations, potentially aiding hair regrowth after injury, disease, or aging.

research Macroenvironmental Regulation of Hair Cycling and Collective Regenerative Behavior

42 citations , January 2014 in “Cold Spring Harbor Perspectives in Medicine”

This abstract omits specific findings and does not provide new research results.

research Regionalization of the Skin

26 citations , December 2013 in “Seminars in cell & developmental biology”

This article reviews how anatomical differences in skin arise and persist, and suggests the underlying molecular positional code is more complex than apparent, but reports no new research findings.

research Distinct Fibroblast Lineages Determine Dermal Architecture in Skin Development and Repair

1235 citations , December 2013 in “Nature”

This study found that skin fibroblasts in mice arise from two distinct lineages which contribute differently to dermal structure and repair, impacting hair follicle formation during wound healing.

research Hair Follicle Signaling Networks: A Dermal Papilla–Centric Approach

28 citations , September 2013 in “Journal of Investigative Dermatology”

This research reviews the roles of dermal papilla signaling in hair follicle development and suggests new genetic tools could advance bioengineering therapies for alopecia, but it reports no new results.

research Fgf9 From Dermal γδ T Cells Induces Hair Follicle Neogenesis After Wounding

237 citations , June 2013 in “Nature Medicine”

This study found that fibroblast growth factor 9, initially secreted by γδ T cells, plays a key role in modulating hair follicle regeneration in mice after skin wounds.

research Position Effect on FGF13 Associated with X-Linked Congenital Generalized Hypertrichosis

44 citations , April 2013 in “Proceedings of the National Academy of Sciences of the United States of America”

This study found a significant association between reduced FGF13 levels and X-linked congenital generalized hypertrichosis, suggesting FGF13's potential role in hair follicle growth and the hair cycle.

research Dermal Papilla Cell Number Specifies Hair Size, Shape, and Cycling, and Its Reduction Causes Follicular Decline

211 citations , April 2013 in “Development”

In this study, researchers found that the number of dermal papilla cells in hair follicles determines hair size and shape in mice, suggesting potential avenues for addressing hair loss.

research Mesenchymal–Epithelial Interactions During Hair Follicle Morphogenesis and Cycling

300 citations , August 2012 in “Seminars in Cell & Developmental Biology”

This review discusses mesenchymal–epithelial interactions in hair follicle development and cycling, highlighting recent insights without reporting new experimental results.

research Live Imaging of Stem Cell and Progeny Behavior in Physiological Hair-Follicle Regeneration

305 citations , June 2012 in “Nature”

This study reports that hair regeneration in live mice involves spatially regulated stem cell divisions and requires mesenchymal interactions, observed in real-time using a novel non-invasive imaging method.

research Fully Functional Hair Follicle Regeneration Through the Rearrangement of Stem Cells and Their Niches

179 citations , April 2012 in “Nature Communications”

This study demonstrates the potential of using bioengineered follicles from adult tissue-derived stem cells for fully functional hair regeneration, illustrating possible applications in organ replacement therapy.

research Polyclonal Origin and Hair Induction Ability of Dermal Papillae in Neonatal and Adult Mouse Back Skin

24 citations , April 2012 in “Developmental Biology”

This animal study found that dermal papilla cells in hair follicles of chimeric mice can originate from various fibroblasts in the skin, challenging assumptions about their specific lineage.

research New Activators and Inhibitors in the Hair Cycle Clock: Targeting Stem Cells’ State of Competence

68 citations , April 2012 in “Journal of Investigative Dermatology”

The study reports that Fgf18 and Tgf-β2 signaling pathways in hair follicle stem cells have opposing effects on the timing of hair cycle transitions, influencing the shift from telogen to anagen phases.

Dermal β-Catenin Activity in Response to Epidermal Wnt Ligands Is Required for Fibroblast Proliferation and Hair Follicle Initiation

research Dermal β-Catenin Activity in Response to Epidermal Wnt Ligands Is Required for Fibroblast Proliferation and Hair Follicle Initiation

207 citations , March 2012 in “Development”

In this mouse study, researchers found that dermal Wnt signaling/β-catenin activity is essential for fibroblast proliferation and initiating hair follicle formation by interacting with epidermal Wnt ligands.

Clonal Growth of Dermal Papilla Cells in Hydrogels Reveals Intrinsic Differences Between Sox2-Positive and Sox2-Negative Cells In Vitro and In Vivo

research Clonal Growth of Dermal Papilla Cells in Hydrogels Reveals Intrinsic Differences Between Sox2-Positive and Sox2-Negative Cells In Vitro and In Vivo

68 citations , December 2011 in “Journal of Investigative Dermatology”

This study reported that a three-dimensional hydrogel culture system supports the growth and maintenance of distinct dermal papilla cell types, crucial for skin reconstitution assays in neonatal mice.

research Reprogramming Adult Dermis to a Neonatal State Through Epidermal Activation of Beta-Catenin

128 citations , October 2011 in “Development”

This study found that adult mouse dermis can be reprogrammed by epidermal cues to resemble neonatal dermis, with changes in fibroblast proliferation and extracellular matrix composition.

research Self-Organizing and Stochastic Behaviors During the Regeneration of Hair Stem Cells

176 citations , April 2011 in “Science”

This study found that in a population of hair follicles, regenerative cycling stages are regulated by both intrinsic and extrinsic signals, with WNT/BMP signaling mediating interactions among follicles for adaptability.

Bald Scalp in Men with Androgenetic Alopecia Retains Hair Follicle Stem Cells but Lacks CD200-Rich and CD34-Positive Hair Follicle Progenitor Cells

research Bald Scalp in Men with Androgenetic Alopecia Retains Hair Follicle Stem Cells but Lacks CD200-Rich and CD34-Positive Hair Follicle Progenitor Cells

235 citations , January 2011 in “Journal of Clinical Investigation”

This study found that androgenetic alopecia may involve a defect in the conversion of hair follicle stem cells to progenitor cells, as demonstrated by a reduced presence of progenitor cells in bald scalp samples.

research Microenvironmental Reprogramming of Thymic Epithelial Cells to Skin Multipotent Stem Cells

116 citations , August 2010 in “Nature”

Scientists turned rat thymus cells into stem cells that can help repair skin and hair.

research De Novo Production of Dermal Papilla Cells During the Anagen Phase of the Hair Cycle

41 citations , June 2010 in “Journal of Investigative Dermatology”

This study suggests that new cells are incorporated into the dermal papilla during the early anagen phase of the hair cycle, which may influence hair growth consistency and follicle size changes.

research Epidermal Patterning and Induction of Different Hair Types During Mouse Embryonic Development

81 citations , September 2009 in “Birth defects research”

This review discusses the mechanisms behind hair patterning during mouse embryonic development and reports no new experimental findings.

research Sox2-Positive Dermal Papilla Cells Specify Hair Follicle Type in Mammalian Epidermis

338 citations , July 2009 in “Development”

This study demonstrates that Sox2-positive dermal papilla cells specify particular hair follicle types by showing heterogeneity in gene expression and pathway activation in these cells.

research From Telogen to Exogen: Mechanisms Underlying Formation and Subsequent Loss of the Hair Club Fiber

81 citations , April 2009 in “Journal of Investigative Dermatology”

This review discusses the shedding phase of the hair cycle, known as exogen, and reports no new findings while analyzing related processes like club fiber formation and release.

research BMP2 And BMP7 Play Antagonistic Roles In Feather Induction

88 citations , July 2008 in “Development”

This study shows that BMP2 and BMP7 play complex, necessary roles in feather development by regulating dermal condensation formation, with BMP7 acting early as a chemoattractant and BMP2 halting cell migration.

research Differing Responses of Human Follicular and Nonfollicular Scalp Cells in an In Vitro Wound Healing Assay: Effects of Estrogen on Vascular Endothelial Growth Factor Secretion

30 citations , March 2008 in “Wound Repair and Regeneration”

This study found that estrogen affected cell behaviors differently in a scratch-wound assay, increasing VEGF secretion in follicular dermal papilla cells but decreasing it in wounded dermal sheath cells.

research Dynamic Expression of the Zinc-Finger Transcription Factor Trps1 During Hair Follicle Morphogenesis and Cycling

46 citations , November 2007 in “Gene Expression Patterns”

This study observed that Trps1 gene expression in mice is precisely regulated in skin development, particularly during hair follicle morphogenesis, with distinct localization patterns in different cell types.

research A Guide to Assessing Damage Response Pathways of the Hair Follicle: Lessons From Cyclophosphamide-Induced Alopecia in Mice

106 citations , June 2005 in “Journal of Investigative Dermatology”

This study defines classification criteria for hair follicle dystrophy using a mouse model of chemotherapy-induced alopecia, providing tools for standardized hair damage assessment.

research Genetic Variation in the Human Androgen Receptor Gene Is the Major Determinant of Common Early-Onset Androgenetic Alopecia

195 citations , June 2005 in “American Journal of Human Genetics”

Genetic variation in the androgen receptor gene mainly causes early-onset hair loss, with maternal inheritance playing a key role.

research Transformation of Amnion Epithelium into Skin and Hair Follicles

33 citations , December 2004 in “Differentiation”

In this study, mouse amnion epithelium was successfully transformed into skin and hair follicles when associated with hair-forming dermis, revealing the necessity of specific influences for follicle formation.

research Cultured Human and Rat Tooth Papilla Cells Induce Hair Follicle Regeneration and Fiber Growth

48 citations , December 2004 in “Differentiation”

This study found that cultured dental papilla cells from various mammals can induce hair follicle regeneration and influence tissue formation, with outcomes dependent on donor age, tooth type, and host environment.

research Transient Activation of Beta-Catenin Signaling in Adult Mouse Epidermis Induces New Hair Follicles, Continuous Activation Maintains Tumors

335 citations , March 2004 in “Development”

This study found that continuous β-catenin signaling in adult mouse epidermis can reprogram hair follicles to form benign tumors, which regress after the signaling is discontinued.

research Cell Movement in the Hair Follicle Dermis: More Than a Two-Way Street?

47 citations , December 2003 in “Journal of Investigative Dermatology”

DS cells in hair follicles can help form and restore hair, especially in hair loss conditions.

research Molecular Control of Epithelial-Mesenchymal Interactions During Hair Follicle Cycling

277 citations , June 2003 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings”

This article reviews the role of epithelial-mesenchymal interactions in hair follicle morphogenesis and the hair cycle, suggesting potential paths for developing treatments for hair growth disorders but providing no new clinical findings.

Plasticity and Cytokinetic Dynamics of the Hair Follicle Mesenchyme During the Hair Growth Cycle: Implications for Growth Control and Hair Follicle Transformations

research Plasticity and Cytokinetic Dynamics of the Hair Follicle Mesenchyme During the Hair Growth Cycle: Implications for Growth Control and Hair Follicle Transformations

54 citations , June 2003 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings”

This speculative review discusses hair cycle-dependent fibroblast dynamics and possible impacts on human hair growth, synthesizing current literature without presenting new clinical findings.

research Molecular Mechanisms Regulating Hair Follicle Development

854 citations , February 2002 in “The journal of investigative dermatology/Journal of investigative dermatology”

This review summarizes recent advances in understanding the molecular mechanisms of hair follicle formation and discusses potential future clinical applications for treating hair loss and skin tumors, but it reports no new clinical results.

research Possible Mechanisms of Miniaturization During Androgenetic Alopecia or Pattern Hair Loss

116 citations , September 2001 in “Journal of The American Academy of Dermatology”

This study suggests that miniaturization in pattern hair loss may occur abruptly and can be reversed with treatment, as supported by histologic evidence in finasteride-responsive patients.

research The Role of the Hairless (Hr) Gene in the Regulation of Hair Follicle Catagen Transformation

166 citations , July 1999 in “American Journal Of Pathology”

This study found that the loss of a functional hr gene in mice leads to premature and abnormal hair follicle regression, disrupting normal hair cycling and architecture.

research Human Hair Follicle Regeneration Following Amputation and Grafting into the Nude Mouse

72 citations , December 1996 in “Journal of Investigative Dermatology”

This study observed that human hair follicles were able to regenerate fiber-forming structures after the bulb was amputated and transplanted onto athymic mice, suggesting a general regenerative capacity.

research A Comparison of the Culture and Growth of Dermal Papilla Cells from Hair Follicles from Non-Balding and Balding (Androgenetic Alopecia) Scalp

30 citations , March 1996 in “British Journal of Dermatology”

research Sheep Vibrissa Dermal Papillae Induce Hair Follicle Formation in Heterotypic Skin Equivalents

21 citations , December 1994 in “British Journal of Dermatology”

In this study, cultured skin equivalents with ovine hair follicle dermal papillae grafted onto nude mice developed follicle-like structures, suggesting a potential model for studying hair follicle development.

research Retinoic Acid and Mouse Skin Morphogenesis: Expression Pattern of Retinoic Acid Receptor Genes During Hair Vibrissa Follicle, Plantar, and Nasal Gland Development

24 citations , July 1994 in “Journal of Investigative Dermatology”

research Induction of Follicle Formation and Hair Growth by Vibrissa Dermal Papillae Implanted into Rat Ear Wounds: Vibrissa-Type Fibres Are Specified

125 citations , August 1992 in “Development”

This study found that implanting isolated adult rat dermal papillae into ear cuts led to the emergence of unusually large vibrissa-type hair follicles, demonstrating their capacity to induce specific hair fiber characteristics.

research Physiology of Development of the Feather V: Experimental Morphogenesis

81 citations , April 1941 in “Physiological zoology”

Experiments can shape how feathers grow and develop.