The Historical Studies Underpinning the Concept of Hair Follicle Neogenesis

    January 2022 in “ Springer eBooks
    Claire A. Higgins, Colin A.B. Jahoda
    TLDR Fibroblast growth factors are crucial for hair follicle development and regeneration.
    The document reviews historical studies on hair follicle neogenesis, highlighting the role of fibroblast growth factors (FGFs) in dermal condensation and hair follicle development. Key findings include FGF-2's ability to induce dermal condensations, FGF20's role in forming primary and secondary dermal condensations, and FGF9's involvement in hair follicle neogenesis post-wounding. The studies collectively underscore the importance of epithelial-mesenchymal interactions and molecular signaling pathways in hair follicle morphogenesis and regeneration.
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