Reprogramming of Three-Dimensional Microenvironments for In Vitro Hair Follicle Induction

    June 2022 in “ bioRxiv (Cold Spring Harbor Laboratory) ”
    Tatsuto Kageyama, Akihiro Shimizu, Riki Anakama … Junji Fukuda

    Preprint — not peer reviewed. This was posted to a preprint server or data repository. It has not been through a journal's review process, and its findings may change or not hold up.

    Studysummary This study found that modulating epithelial and mesenchymal cell interactions in vitro enabled nearly 100% efficient induction of hair follicles, suggesting potential applications for understanding and testing hair growth and graying.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 20

    1. Generation of Skin Organoids: Potential Opportunities and Challenges Frontiers in cell and developmental biology · 2021
    2. Back to the Future: From Appendage Development Toward Future Human Hair Follicle Neogenesis Frontiers in Cell and Developmental Biology · 2021
    3. Stress-Sensing in the Human Greying Hair Follicle: Ataxia Telangiectasia Mutated (ATM) Depletion in Hair Bulb Melanocytes in Canities-Prone Scalp Scientific reports · 2020
    4. Effects of Platelet-Rich Plasma on In Vitro Hair Follicle Germ Preparation for Hair Regenerative Medicine Journal of Bioscience and Bioengineering · 2020
    5. Hair-Bearing Human Skin Generated Entirely From Pluripotent Stem Cells Nature · 2020
    6. PI3K/Akt Signaling Pathway Is Essential for De Novo Hair Follicle Regeneration Stem Cell Research & Therapy · 2020
    7. A Novel Mouse Model Demonstrates That Oncogenic Melanocyte Stem Cells Engender Melanoma Resembling Human Disease Nature Communications · 2019
    8. Preparation of Hair Beads and Hair Follicle Germs for Regenerative Medicine Biomaterials · 2019
    9. Inducing Hair Follicle Neogenesis with Secreted Proteins Enriched in Embryonic Skin Biomaterials · 2018
    10. Hair Follicle Development in Mouse Pluripotent Stem Cell-Derived Skin Organoids Cell Reports · 2018
    11. Spontaneous Hair Follicle Germ Formation In Vitro, Enabling The Large-Scale Production Of HFGs For Regenerative Medicine Biomaterials · 2017
    12. Self-Organization Process in Newborn Skin Organoid Formation Inspires Strategy to Restore Hair Regeneration of Adult Cells Proceedings of the National Academy of Sciences of the United States of America · 2017
    13. Hair Germ Model In Vitro via Human Postnatal Keratinocyte-Dermal Papilla Interactions: Impact of Hyaluronic Acid Stem cells international · 2017
    14. Wnt Signaling in Skin Development, Homeostasis, and Disease Cold Spring Harbor Perspectives in Biology · 2012
    15. Fully Functional Hair Follicle Regeneration Through the Rearrangement of Stem Cells and Their Niches Nature Communications · 2012
    16. Dermal β-Catenin Activity in Response to Epidermal Wnt Ligands Is Required for Fibroblast Proliferation and Hair Follicle Initiation Development · 2012
    17. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009
    18. Hair Morphogenesis In Vitro: Formation of Hair Structures Suitable for Implantation Regenerative Medicine · 2008
    19. Enrichment for Living Murine Keratinocytes from the Hair Follicle Bulge with the Cell Surface Marker CD34 Journal of Investigative Dermatology · 2003
    20. Molecular Mechanisms Regulating Hair Follicle Development ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2002

    Related research 6

    1. Morphogenesis, Growth Cycle, and Molecular Regulation of Hair Follicles Frontiers in Cell and Developmental Biology · 2022
    2. Dermal Papilla-Derived Wnt Ligands Are Required for Adult Hair Follicle Growth Journal of Investigative Dermatology · 2016
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