A Novel Mouse Model Demonstrates That Oncogenic Melanocyte Stem Cells Engender Melanoma Resembling Human Disease

    November 2019 in “ Nature Communications ”
    Qi Sun, Wendy Lee, Yasuaki Mohri, Makoto Takeo, Chae Ho Lim, Xiaowei Xu, Peggy Myung, Radhika P. Atit, Makoto M. Taketo, Rana S. Moubarak, Markus Schöber, Iman Osman, Denise Gay, Dieter Saur, Emi K. Nishimura, Mayumi Ito
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    TLDR Oncogenic melanocyte stem cells can develop into melanoma similar to human cases.
    The study utilized a c-Kit-CreER-driven mouse model to demonstrate that oncogenic melanocyte stem cells (McSCs) could indeed form melanoma, addressing previous contradictory findings. The research showed that these McSCs expanded within their niche and developed into epidermal melanomas that invaded the dermis. It was found that normal Wnt and Endothelin signals, typically active during hair growth, were co-opted to facilitate the malignant transformation of McSCs. Molecular profiling indicated that the murine McSC-derived melanoma closely resembled human melanoma in terms of heterogeneity and gene signatures. This provided experimental support for the human melanoma progression model and offered insights into the transformation and diversity of McSC-derived melanoma.
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