The Roles of Non-Coding RNA in the Development and Regeneration of Hair Follicles: Current Status and Further Perspectives

    October 2021 in “ Frontiers in Cell and Developmental Biology ”
    Min Yang, Tingting Weng, Wei Zhang, Manjia Zhang, Xin He, Chunmao Han, Xingang Wang
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    TLDR Non-coding RNAs are important for hair growth and could lead to new hair loss treatments, but more research is needed.
    The document discusses the significant role of non-coding RNAs (ncRNAs), including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), in the development and regeneration of hair follicles. These ncRNAs regulate hair follicle development, cycling, and regeneration by controlling the expression of genes related to hair growth and loss. The study suggests that understanding the mechanisms of ncRNAs in hair follicle biology could lead to new therapeutic strategies for hair loss disorders such as alopecia. However, further research is needed to fully understand these mechanisms and to develop effective ncRNA-based therapies.
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