TLDR PlncRNA-1 helps hair follicle stem cells grow and develop by controlling a specific cell signaling pathway.
The 2017 study explored how the long non-coding RNA (lncRNA) PlncRNA-1 affects hair follicle stem cells (HFSCs). It was discovered that PlncRNA-1 is involved in the proliferation and differentiation of HFSCs by regulating the TGF-β1-mediated Wnt/β-catenin signaling pathway. When PlncRNA-1 was introduced into HFSCs, it increased the expression of TGF-β1, Wnt, and β-catenin, which in turn stimulated the cells' proliferation and differentiation. Conversely, the application of a TGF-β1 inhibitor, LY2109761, reversed these effects, indicating the importance of the TGF-β1 pathway in the process. The study did not specify the number of cells or participants involved.
3 citations,
August 2014 in “Cellular reprogramming” Hair follicle stem cells need all reprogramming factors to become pluripotent.
173 citations,
January 2014 in “Nature Cell Biology” Wnt signaling controls whether hair follicle stem cells stay inactive or regenerate hair.
95 citations,
May 2012 in “British Journal of Dermatology” Androgens block hair growth by disrupting cell signals; targeting GSK-3 may help treat hair loss.
16 citations,
January 2007 in “Dermatology” Scientists have made progress in understanding hair follicle stem cells, identifying specific genes and markers, and suggesting their use in treating hair and skin conditions.
92 citations,
December 2005 in “The Journal of clinical investigation/The journal of clinical investigation” Human hair follicle stem cells can be isolated using specific markers for potential therapeutic use.
31 citations,
August 2021 in “Stem Cell Research & Therapy” The conclusion is that understanding how hair follicle stem cells live or die is important for maintaining healthy tissue and repairing injuries, and could help treat hair loss, but there are still challenges to overcome.
4 citations,
August 2022 in “Cells” lncRNA2919 slows down rabbit hair growth by stopping cell growth and causing cell death.
May 2022 in “Cardiovascular Toxicology” 16 citations,
September 2020 in “Animals” circRNA-1926 helps goat stem cells turn into hair follicles by affecting miR-148a/b-3p and CDK19.
August 2022 in “International Journal of Molecular Sciences” DNA methylation controls lncRNA2919, which negatively affects hair growth.
