DNA Methylation Mediates LncRNA2919 Regulation of Hair Follicle Regeneration

The study explores the role of lncRNA2919 in hair follicle (HF) regeneration using an in vivo rabbit model, finding that lncRNA2919 negatively impacts HF regeneration by reducing HF depth and density, delaying hair shaft growth, and extending the transition from telogen to anagen. DNA methylation of the lncRNA2919 promoter inhibits its expression, with specific CpG sites identified as key regulators. Demethylation increases lncRNA2919 expression, and the transcription factor EGR1 binds to the lncRNA2919 promoter, enhancing its activity. These findings underscore the importance of DNA methylation in regulating lncRNA2919 and its role in HF biology, offering insights for potential hair disease treatments and improvements in animal wool production.