LncRNA-000133 from Secondary Hair Follicle of Cashmere Goat: Identification, Regulatory Network, and Its Effects on Inductive Property of Dermal Papilla Cells

In the 2019 study, researchers discovered a novel long noncoding RNA (lncRNA-000133) in the secondary hair follicle of Cashmere goats, which showed higher expression during the anagen phase than the telogen phase, indicating its potential role in hair growth. Methylation analysis suggested that methylation of the 5' regulatory region might suppress lncRNA-000133 expression. The study also revealed a regulatory network involving lncRNA-000133, microRNAs, and their target genes. Overexpression of lncRNA-000133 in dermal papilla cells increased the expression of genes related to hair follicle development, although it did not affect all genes associated with the inductive properties of these cells. The findings imply that lncRNA-000133 may influence hair follicle development and cashmere fiber growth through a complex interaction network, but further research is needed to fully understand its role. The number of subjects or samples used in the study was not specified.