Wnt1a Maintains Characteristics of Dermal Papilla Cells That Induce Mouse Hair Regeneration in a 3D Preculture System
June 2015
in “
Journal of Tissue Engineering and Regenerative Medicine
”
TLDR Wnt1a helps keep cells that can grow hair effective for potential hair loss treatments.
The study from June 29, 2015, explored the use of Wnt1a to preserve the hair-inducing properties of dermal papilla (DP) cells in a 3D culture system. Researchers used a conditioned medium from Wnt1a-expressing bone marrow mesenchymal stem cells (Wnt-CM) to treat DP cells, which were then combined with epidermal (EP) cells in a collagen-chitosan scaffold (CCS). This combination formed dermal condensates and a proliferative cell layer in vitro. When transplanted into nude mice, the CCS cells induced hair regeneration. The study concluded that Wnt-CM effectively maintains the hair induction ability of DP cells during culture expansion, suggesting its potential for large-scale preparation of cells for hair loss treatment. However, the number of mice used in the study was not mentioned.
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