Hair Follicle Regeneration in Skin Grafts: Current Concepts and Future Perspectives

February 2012 in “ Tissue Engineering Part B-reviews ”

Seyed Babak Mahjour, Fariborz Ghaffarpasand, Hongjun Wang

TLDR Hair follicle regeneration in skin grafts may be possible using stem cells and tissue engineering.

This document discusses the potential for hair follicle regeneration in skin grafts through tissue engineering and stem cell technology. It highlights the importance of understanding the molecular mechanisms involved in hair follicle development and growth, including the role of various growth factors and signaling pathways. The document also discusses the potential use of stem cells and tissue engineering techniques for hair follicle regeneration. Overall, the document emphasizes the need for further research in this area to develop effective treatments for hair loss and alopecia.

View this study on europepmc.org →

Discuss this study in the Community →

Cited in this study

15 / 15 results

research Review of Hair Follicle Dermal Cells

321 citations , January 2010 in “Journal of Dermatological Science”

Dermal cells are key in controlling hair growth and could potentially be used in hair loss treatments, but more research is needed to improve hair regeneration methods.

research The Hair Follicle as a Dynamic Mini-Organ

759 citations , February 2009 in “Current Biology”

Hair follicles are complex, dynamic mini-organs that help us understand cell growth, death, migration, and differentiation, as well as tissue regeneration and tumor biology.

research Hair Morphogenesis In Vitro: Formation of Hair Structures Suitable for Implantation

43 citations , September 2008 in “Regenerative Medicine”

Scientists created early-stage hairs from mouse cells that grew into normal, pigmented hair when implanted into other mice.

research Hair Follicle Regeneration Using Grafted Rodent and Human Cells

96 citations , September 2007 in “Journal of Investigative Dermatology”

Grafted rodent and human cells can regenerate hair follicles, but efficiency decreases with age.

research Defining Hair Follicles in the Age of Stem Cell Bioengineering

49 citations , September 2007 in “Journal of Investigative Dermatology”

The study found that bioengineered hair follicles work when using cells from the same species but have issues when combining human and mouse cells.

research Biology of the Hair Follicle: The Basics

224 citations , March 2006 in “Seminars in Cutaneous Medicine and Surgery”

The document concludes that understanding hair follicle biology can lead to better hair loss treatments.

research The Hair Growth Promoting Effect of Ascorbic Acid 2-Phosphate, a Long-Acting Vitamin C Derivative

33 citations , February 2006 in “Journal of Dermatological Science”

A long-acting Vitamin C derivative helps hair grow by stimulating cells and increasing growth factors.

research Hairless Triggers Reactivation of Hair Growth by Promoting Wnt Signaling

137 citations , September 2005 in “Proceedings of the National Academy of Sciences of the United States of America”

The HR protein helps hair grow by blocking a hair growth inhibitor, aiding in hair follicle regeneration.

research Organogenesis From Dissociated Cells: Generation of Mature Cycling Hair Follicles From Skin-Derived Cells

205 citations , May 2005 in “Journal of Investigative Dermatology”

Scientists have found a way to create hair follicles from skin cells of newborn mice, which can grow and cycle naturally when injected into adult mouse skin.

research Rooster Feathering, Androgenic Alopecia, And Hormone-Dependent Tumor Growth: What Is In Common?

23 citations , December 2004 in “Differentiation”

Sex hormones affect hair and feather growth and may help manage alopecia and hormone-dependent cancers.

research Effect of Minoxidil on Proliferation and Apoptosis in Dermal Papilla Cells of Human Hair Follicle

149 citations , April 2004 in “Journal of Dermatological Science”

Minoxidil boosts hair growth by increasing cell production and survival.

research Cultured Peribulbar Dermal Sheath Cells Can Induce Hair Follicle Development and Contribute to the Dermal Sheath and Dermal Papilla

208 citations , December 2003 in “Journal of Investigative Dermatology”

Certain cells from hair follicles can create new hair and contribute to hair growth when implanted in mice.

research DERMAL-EPIDERMAL INTERACTIONS

114 citations , October 1996 in “Dermatologic clinics”

Hair loss is mainly caused by hormones, autoimmune issues, and chemotherapy, and needs more research for treatments.

research An efficient method for isolation of hair papillae and follicle epithelium from human scalp specimens

8 citations , September 1993 in “British journal of dermatology/British journal of dermatology, Supplement”

A new method helps isolate key hair components to study hair growth and loss.

research Dermal-Epidermal Interactions--Follicle Derived Cell Populations in the Study of Hair-Growth Mechanisms.

28 citations , July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology”

Dermal papilla cells are crucial for hair growth and can induce new hair follicles.

4 / 4 results

research Hair-Follicle Dermal Papilla and Sheath Fibroblasts Provide a Supportive Microenvironment for Human Skin Regeneration

3 citations , May 2017 in “British journal of dermatology/British journal of dermatology, Supplement”

Certain cells around hair follicles help improve skin regeneration for potential use in skin grafts.