Preparation of Scaffolds from Human Hair Proteins for Tissue-Engineering Applications

    April 2008 in “ Biomedical Materials ”
    Vipin Kumar Verma, Poonam Verma, Pratima Ray, Alok R. Ray
    TLDR Human hair proteins can be used to create scaffolds that support cell growth for tissue engineering.
    The study focused on using human hair proteins to create scaffolds for tissue-engineering applications. These proteins were tested for cellular compatibility using NIH3T3 mice fibroblast cells. Characterization techniques revealed keratin molecular weights of 40-60 kDa and matrix proteins of 15-30 kDa, with keratin pIs between 4.5-5.3. The proteins formed sponges through lyophilization, and their hydrophilic nature was confirmed with a contact angle of 37 degrees. The protein-coated surfaces supported enhanced cell growth and three-dimensional morphology, indicating their potential as scaffolds due to improved cell-cell and cell-matrix interactions.
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