Titanium Dioxide Nanoparticles: A Promising Candidate for Wound Healing Applications

January 2025 in “ Burns & Trauma ”

Hamed Nosrati, Morteza Heydari

titanium dioxide nanoparticles antioxidant anti-inflammatory antimicrobial tissue regeneration scaffolds dressings tissue engineering TiO2 NPs

TLDR Titanium dioxide nanoparticles can help heal wounds faster and better.

Titanium dioxide nanoparticles (TiO2 NPs) are promising for wound healing due to their antioxidant, anti-inflammatory, and antimicrobial properties. They protect against oxidative stress, inhibit protein denaturation, and prevent infections, promoting faster wound healing. TiO2 NPs enhance mechanical properties of scaffolds and dressings, support cell proliferation, migration, and angiogenesis, and improve re-epithelialization and collagen deposition. Studies in animal models show accelerated wound closure and reduced inflammation. However, further research is needed to understand their potential toxicity and optimize clinical use.

View this study on academic.oup.com →

Discuss this study in the Community →

Research cited in this study

6 / 6 results

research A Compositionally Synergistic Approach for the Development of a Multifunctional Bilayer Scaffold with Antibacterial Property for Infected and Chronic Wounds

54 citations, May 2021 in “Chemical Engineering Journal”

The developed scaffold effectively treats chronic wounds by promoting healing and preventing infection.

research Wound Healing: A Cellular Perspective

1160 citations, November 2018 in “Physiological Reviews”

The document concludes that better targeted treatments are needed for wound healing, and single-cell technologies may improve cell-based therapies.

research Fibroblasts and Wound Healing: An Update

146 citations, July 2018 in “Regenerative Medicine”

Understanding different types of skin cells, especially fibroblasts, can lead to better treatments for wound healing and less scarring.

research Anatomy and Function of the Skin

40 citations, January 2016 in “Elsevier eBooks”

The skin is the largest organ, protecting the body, regulating temperature, and producing hormones.

research Advances in Skin Grafting and Treatment of Cutaneous Wounds

518 citations, November 2014 in “Science”

Skin grafting and wound treatment have improved, but we need more research to better understand wound healing and create more effective treatments.

research Anatomy and Physiology of the Skin

277 citations, July 2011 in “Journal of the Dermatology Nurses’ Association”

The skin's layers protect, sense, and regulate the body's internal balance, but can be prone to cancer.

Similar Research

5 / 334 results

research Accelerated Wound Healing Using Nanoparticles

10 citations, January 2016 in “Elsevier eBooks”

Nanoparticles can speed up wound healing and deliver drugs effectively but may have potential toxicity risks.

research Nanotechnology Approaches in Chronic Wound Healing

110 citations, April 2020 in “Advances in Wound Care”

Nanotechnology shows promise for better chronic wound healing but needs more research.

research The Anti-Atopic Lotions Containing Fucoidan Extracted from Ecklonia Cava Impact on Hairless Mice with Atopic Dermatitis

April 2011 in “한국생물공학회 학술대회”

Lotion with fucoidan from brown seaweed improved skin and reduced allergy symptoms in mice with dermatitis.

research Nanotechnology-Based Techniques for Hair Follicle Regeneration

October 2023 in “Biomaterials”

Nanotechnology could improve hair regrowth but faces challenges like complexity and safety concerns.

research A Concise Review on Tissue Engineered Artificial Skin Grafts for Chronic Wound Treatment: Can We Reconstruct Functional Skin Tissue In Vitro?

133 citations, July 2020 in “Cells”

Creating fully functional artificial skin for chronic wounds is still very challenging.

Titanium Dioxide Nanoparticles: A Promising Candidate for Wound Healing Applications

Research cited in this study

research A Compositionally Synergistic Approach for the Development of a Multifunctional Bilayer Scaffold with Antibacterial Property for Infected and Chronic Wounds

research Wound Healing: A Cellular Perspective

research Fibroblasts and Wound Healing: An Update

research Anatomy and Function of the Skin

research Advances in Skin Grafting and Treatment of Cutaneous Wounds

research Anatomy and Physiology of the Skin

Related Community Posts Join

community Titanium Dioxide Free Finasteride

community Out of curiosity, why are Finasteride pills formulated as small tablets, while Dutasteride pills are much larger soft gel capsules?

community Success sttory – 22 to 27

community What size of derma roller is proper for hair regrowth?

community Progress over 4 months into dutasteride 0.5mg every other day