TLDR Nanotechnology shows promise for better chronic wound healing but needs more research.
The document reviewed various nanotechnology approaches for chronic wound healing, particularly in diabetic models. It highlighted the potential of nanoparticles, nanofibers, and nanocomposites in enhancing wound healing through antimicrobial activity, drug delivery, and tissue regeneration. Key findings included the use of silver, gold, copper, and zinc oxide nanoparticles for their antibacterial properties and promotion of angiogenesis and collagen deposition. Nanofibers and liposomes were noted for their ability to mimic the extracellular matrix and provide sustained release of therapeutic agents. Despite promising preclinical results, the review emphasized the need for further research and clinical trials to confirm the efficacy and safety of these nanotechnology-based treatments in humans.
86 citations,
March 2018 in “ACS Biomaterials Science & Engineering” MDP hydrogel heals wounds faster and better than other treatments in diabetic mice.
355 citations,
August 2013 in “Acta Biomaterialia” The nanofibers with two growth factors improved wound healing by supporting structure, preventing infection, and aiding tissue growth.
33 citations,
September 2012 in “Wound Repair and Regeneration” Applying calreticulin can speed up wound healing in diabetics.
48 citations,
September 2017 in “Frontiers in Bioscience” Nanoparticles show promise for better wound healing, but more research is needed to ensure safety and effectiveness.
January 2024 in “Authorea (Authorea)” Nanomaterials can significantly improve wound healing and future treatments may include smart, real-time monitoring.
20 citations,
January 2022 in “Polymers” Nanoparticles added to natural materials like cellulose and collagen can improve cell growth and wound healing, but more testing is needed to ensure they're safe and effective.
2 citations,
June 2023 in “Pharmaceutics” Nanofiber scaffolds help wounds heal by delivering drugs directly to the injury site.
50 citations,
February 2022 in “Nanomaterials” Nanomaterials show promise in improving wound healing but require more research on their potential toxicity.
