The Effect of Nanoparticle-Incorporated Natural-Based Biomaterials on Cells and Activated Pathways: A Systematic Review

    January 2022 in “ Polymers ”
    Nur Izzah Md Fadilah, Isma Liza Mohd Isa, Wan Safwani Wan Kamarul Zaman, Yasuhiko Tabata, Mh Busra Fauzi
    Image of study
    TLDR Nanoparticles added to natural materials like cellulose and collagen can improve cell growth and wound healing, but more testing is needed to ensure they're safe and effective.
    This systematic review discusses the benefits of incorporating nanoparticles into natural-based biomaterials for applications in wound healing, tissue engineering, and regenerative medicine. The biomaterials used included cellulose, collagen, and natural polymers like chitosan and alginate, and were fabricated into nanofibers, nanocomposite scaffolds, hydrogels, and films. The review found that these nanoparticle-incorporated biomaterials enhance cell attachment, viability, proliferation, and migration, and improve the scaffolding's physico-chemical and biological properties. The study also highlighted the role of various signaling pathways, such as Wnt/β-catenin, TGF-β, Notch, and Sonic hedgehog in wound healing. However, concerns about the uncontrolled release of nanoparticles and potential toxicity were raised. The review suggests more in vivo studies and clinical trials are needed to assess the efficacy and safety of these biomaterials.
    Discuss this study in the Community →

    Research cited in this study

    6 / 6 results

    Related Community Posts Join

    6 / 18 results

      community Does anyone know the chemical formula for pelage pp405?

      in Research/Science  14 upvotes 1 year ago
      The conversation discusses the lack of public information on the chemical structure of PP405, a hair loss treatment, and the challenges of synthesizing it without a patent. It also explores a patent related to hydrogen-based topical formulations for reducing oxidative stress and inflammation.

      community The theory that explains everything. Please help me make this big!

      in Research/Science  2452 upvotes 4 years ago
      The post and conversation are about the role of the enzyme 3alpha-hydroxysteroid reductase in hair loss and the potential of compounds like procyanidin B2 and sulforaphane to boost its activity for hair regrowth. Further research is needed to develop effective treatments based on this theory.

      community I was addicted to hair fibers for 11 years

      in Treatment  180 upvotes 7 months ago
      A person used hair fibers for 11 years to hide hair loss, which affected their social life. They had a hair transplant, improving their life, and recommend addressing hair loss directly.

      community Concerns about CosmeRNA safety mechanisms

      in Treatment  3 upvotes 2 years ago
      Concerns about CosmeRNA safety mechanisms and potential side effects. Discussion includes comparisons to Fluridil and questions about nanoparticle specificity and siRNA stability.

      community Pyrilutamide real life results?

      in Research/Science  15 upvotes 3 years ago
      The results of using Pyrilutamide, a hair loss treatment available on the gray market, and other treatments such as Minoxidil, Finasteride and RU58841.

    Similar Research

    5 / 1000+ results