TLDR Innovative biomaterials show promise in healing chronic diabetic foot ulcers.
The document reviews the development and potential of innovative functional biomaterials as therapeutic wound dressings for chronic diabetic foot ulcers (DFUs). It highlights the significant burden of DFUs and the need for advanced treatment options. Various natural and synthetic biomaterials, such as alginate, cellulose, chitosan, collagen, dextran, fibrin, hyaluronic acid, polycaprolactone, and polyethylene glycol, are evaluated for their properties and effectiveness in promoting wound healing. These materials show promise in enhancing angiogenesis, reducing inflammation, and providing antibacterial activity, thereby improving the healing process in diabetic models. Some formulations are also under clinical trials, indicating their potential for future clinical application.
18 citations
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April 2022 in “Frontiers in bioengineering and biotechnology” Gelatin microspheres with stem cells speed up healing in diabetic wounds.
110 citations
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April 2020 in “Advances in Wound Care” Nanotechnology shows promise for better chronic wound healing but needs more research.
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November 2018 in “Physiological Reviews” The document concludes that better targeted treatments are needed for wound healing, and single-cell technologies may improve cell-based therapies.
8 citations
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May 2023 in “Gels” Chitosan hydrogels are promising for repairing blood vessels but need improvements in strength and compatibility.
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June 2023 in “Pharmaceutics” Nanofiber scaffolds help wounds heal by delivering drugs directly to the injury site.
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September 2017 in “Frontiers in Bioscience” Nanoparticles show promise for better wound healing, but more research is needed to ensure safety and effectiveness.
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June 2023 in “Gels” Injectable hydrogels are becoming increasingly useful in medicine for drug delivery and tissue repair.
4 citations
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September 2025 in “Pharmaceutics” Natural hydrogels can improve wound healing but face challenges in becoming widely used in clinics.
