Innovative Functional Biomaterials as Therapeutic Wound Dressings for Chronic Diabetic Foot Ulcers

The document reviews the development and potential of innovative functional biomaterials as therapeutic wound dressings for chronic diabetic foot ulcers (DFUs). It highlights the significant burden of DFUs and the need for advanced treatment options. Various natural and synthetic biomaterials, such as alginate, cellulose, chitosan, collagen, dextran, fibrin, hyaluronic acid, polycaprolactone, and polyethylene glycol, are evaluated for their properties and effectiveness in promoting wound healing. These materials show promise in enhancing angiogenesis, reducing inflammation, and providing antibacterial activity, thereby improving the healing process in diabetic models. Some formulations are also under clinical trials, indicating their potential for future clinical application.