Dual Growth Factor Releasing Multi-Functional Nanofibers for Wound Healing

    August 2013 in “ Acta Biomaterialia ”
    Zhiwei Xie, Christian B. Paras, Wenting Hong, Primana Punnakitikashem, Lee Chun Su, Khanh Vu, Liping Tang, Jian Yang, Kytai T. Nguyen
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    TLDR The nanofibers with two growth factors improved wound healing by supporting structure, preventing infection, and aiding tissue growth.
    The document from 2013 details a study on the development of a biomimetic nanofiber scaffold for wound healing, which releases two growth factors: VEGF for rapid angiogenesis and PDGF-BB for sustained tissue regeneration. The nanofibers, composed of chitosan, poly(ethylene oxide), and PLGA nanoparticles, demonstrated antibacterial properties and supported cell proliferation in vitro. In vivo studies on rat skin wounds showed that the nanofiber meshes significantly enhanced wound healing, with faster epithelium regeneration and more mature collagen formation compared to controls. The study concluded that the dual growth factor-releasing nanofibers could improve wound healing by providing structural support, anti-infection properties, and necessary growth factors at different healing stages. The number of rats used in the in vivo study was not specified in the summary.
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