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Glossary Platelet-Derived Growth Factor

protein that stimulates cell growth and tissue repair

Platelet-Derived Growth Factor (PDGF) is a protein that plays a crucial role in wound healing and the growth of blood vessels. It is released by platelets in the blood and stimulates cells to divide and grow, which is essential for tissue repair and regeneration. PDGF is also involved in various cellular processes, including the development of hair follicles, making it relevant in treatments for conditions like alopecia.

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Research

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research Human hair follicle stem cell differentiation into contractile smooth muscle cells is induced by transforming growth factor-β1 and platelet-derived growth factor BB

19 citations , September 2013 in “Molecular Medicine Reports”

In this study, researchers developed a method to efficiently derive contractile smooth muscle cells from human hair follicle stem cells using TGF-β1 and PDGF-BB, which may advance vascular tissue engineering.

research Effect of 10% calcium gluconate on the activation of platelet-rich plasma obtained at different centrifugation conditions on the expression of platelet derived growth factor-BB (PDGF-BB)

January 2024 in “Universidad Peruana Cayetano Heredia Institutional Repository”

In this in vitro study, simple centrifugation with calcium gluconate activation led to a significantly higher release of PDGF-BB in PRP compared to other methods, which may inform improved clinical PRP preparation protocols.

Platelet-Derived Growth Factor Regulates the Proliferation and Differentiation of Human Melanocytes in a Differentiation-Stage-Specific Manner

research Platelet-derived growth factor regulates the proliferation and differentiation of human melanocytes in a differentiation-stage-specific manner

10 citations , May 2016 in “Journal of Dermatological Science”

This study found that PDGF-BB affects human melanocytes differently depending on their differentiation stage, stimulating melanoblast proliferation but inhibiting melanocyte proliferation while promoting their differentiation.

research Platelet-derived growth factor signaling modulates adult hair follicle dermal stem cell maintenance and self-renewal

37 citations , April 2017 in “npj Regenerative Medicine”

This study found that platelet-derived growth factor signaling is crucial for maintaining the hair follicle dermal stem cell pool and supporting their regenerative capacity.

research Signaling by the Platelet-Derived Growth Factor Receptor Family

January 2009

This review summarizes the roles of PDGF and its receptors in cell development and wound healing, reporting no new research findings; the authors emphasize PDGF's diverse biological functions.

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Learn

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learn Platelet-Rich Plasma

growth factors taken from your blood and injected into your scalp to stimulate hair

What is Platelet-Derived Growth Factor Beta Polypeptide, and how does it help stimulate new hair growth? PDGF-BB is a growth factor that signals to dermal papilla cells and promotes blood-vessel formation; mouse studies report it can push follicles into the growth phase, and human evidence comes only indirectly from PRP trials. No PDGF product is approved for hair restoration and there is no published human trial of PDGF-BB on its own.

learn Beta Polypeptide

learn Epidermal Growth Factor

learn Thymosin Beta 4

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Community Join

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community Growth factors, VEGF, And more,possible permanent cure for people with moderate hairloss?

3 upvotes 1 year ago

The user discusses using dutasteride to stop hair loss and bimatoprost for regrowth. They plan to use VEGF with hydrogels for potentially permanent hair follicle improvement and suggest PRP as an alternative.

community Comprehensive Microneedling Guide

292 upvotes 4 years ago

Microneedling for hair restoration involves daily use of a 0.3 mm device and weekly use of a 0.5 mm device. Combining microneedling with Minoxidil can enhance hair growth.

community A Theory on Why Microneedling Works

175 upvotes 6 years ago

Microneedling may enhance hair regrowth by transferring stem cells to dormant follicles, improving the effects of minoxidil. Users discuss using microneedling with needle lengths around 1.5mm to stimulate hair growth.

community 1 month on minoxidil - progress pictures

in Is this regrowth? 91 upvotes 1 year ago

The user has been using finasteride for years and recently started using minoxidil foam, noticing some increased hair density and vellus hairs after one month. They report no scalp issues or side effects and also use a ketoconazole shampoo weekly.

community My derm said they came up with a new serum that is better then fin? What’s y’all’s thoughts

7 months ago

A new serum claims to enhance hair regrowth by amplifying oxygen delivery, improving the effectiveness of treatments like exosomes and peptides. Users are skeptical, questioning its efficacy compared to established treatments like Minoxidil and Finasteride.

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