Innervated Biomaterials for Improved Cutaneous Wound Healing: A Review of Recent Advancements and Future Prospects

    June 2025 in “ International Journal of Nanomedicine ”
    Boyang Zhang, Kai-Yue Zhang, Qiuyue Liu … Zhao-Liang Guo
    Studysummary This review examines emerging biomaterial strategies designed to support both neural regeneration and cutaneous wound healing, emphasizing their potential to improve sensory function through mechanisms like axonal regrowth and vascular network formation, while noting the need for standardized assessments and clinically translatable designs.
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    Research cited in this study 12

    1. CuCS/Cur Composite Wound Dressings Promote Neuralized Skin Regeneration by Rebuilding the Nerve Cell Factory in Deep Skin Burns Materials today bio · 2024
    2. Neuro-Inspired Biomimetic Microreactor for Sensory Recovery and Hair Follicle Neogenesis Under Skin Burns ACS Nano · 2023
    3. Nerve Growth Factor and Burn Wound Healing: Update of Molecular Interactions With Skin Cells Burns · 2023
    4. Design of a Biofluid-Absorbing Bioactive Sandwich-Structured Zn–Si Bioceramic Composite Wound Dressing for Hair Follicle Regeneration and Skin Burn Wound Healing Bioactive Materials · 2020
    5. Wound Healing: Cellular Mechanisms and Pathological Outcomes Open Biology · 2020
    6. A Concise Review on Tissue Engineered Artificial Skin Grafts for Chronic Wound Treatment: Can We Reconstruct Functional Skin Tissue In Vitro? Cells · 2020
    7. Design of a Multifunctional Biomaterial Inspired by Ancient Chinese Medicine for Hair Regeneration in Burned Skin ACS Applied Materials & Interfaces · 2020
    8. Regeneration of Skin Appendages and Nerves: Current Status and Further Challenges Journal of Translational Medicine · 2020
    9. The Importance of the Neuro-Immuno-Cutaneous System on Human Skin Equivalent Design Cell Proliferation · 2019
    10. Toll-Like Receptor Function in Acute Wounds Advances in wound care · 2017
    11. Advances in Skin Grafting and Treatment of Cutaneous Wounds Science · 2014
    12. Concise Review: Tissue-Engineered Skin and Nerve Regeneration in Burn Treatment Stem Cells Translational Medicine · 2013