A Concise Review on Tissue Engineered Artificial Skin Grafts for Chronic Wound Treatment: Can We Reconstruct Functional Skin Tissue In Vitro?

July 2020 in “ Cells ”

Agata Przekora

tissue-engineered artificial skin grafts chronic wound treatment biomaterials stem cell technologies curcumin neurotensin-loaded collagen dressings stem cell therapies vascularization hair follicles sweat glands artificial skin grafts wound healing collagen dressings stem cell treatments

Studysummary This review discusses the modern approach of skin tissue engineering for chronic wound treatment, focusing on bioengineered artificial skin substitutes and assessing innovations in biomaterials and cell use; it reports no new clinical results. Our plain-language summary of this paper — not a Tressless recommendation.

The review discussed the advancements and challenges in developing tissue-engineered artificial skin grafts for chronic wound treatment, emphasizing the potential of various biomaterials and stem cell technologies to reconstruct functional skin tissue in vitro. Key findings included the beneficial effects of curcumin on wound healing, the role of neurotensin-loaded collagen dressings in reducing inflammation, and the promising results of stem cell therapies. Despite significant progress, the review concluded that achieving fully functional skin tissue remained a complex challenge due to issues like vascularization, integration with host tissue, and the replication of skin appendages such as hair follicles and sweat glands. Further research was needed to optimize these technologies for clinical applications.

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research Regeneration of Skin Appendages and Nerves: Current Status and Further Challenges

71 citations , February 2020 in “Journal of Translational Medicine”

This article reviews current strategies and advancements in regenerating skin appendages and sensory nerves in tissue-engineered skin, highlighting the challenge of restoring skin sensations like pain, temperature, and touch to improve patients’ quality of life.

research Functional Skin Grafts: Where Biomaterials Meet Stem Cells

43 citations , July 2019 in “Stem Cells International”

This review discusses advances and challenges in skin tissue engineering, focusing on developing 3D constructs for functional skin substitutes, and reports no new clinical results.

research Tissue Engineering of Human Hair Follicles Using a Biomimetic Developmental Approach

184 citations , December 2018 in “Nature Communications”

This study demonstrated that enhancing human skin constructs with hair follicles through engineered cell organization and vascularization improved hair growth in immunodeficient mice, suggesting potential advances for treating alopecia and chronic wounds.

research Therapeutic Potential of Stem Cells in Follicle Regeneration

45 citations , August 2018 in “Stem Cells International”

This article reviews the potential of adipose-derived and Wharton’s jelly stem cells in alopecia treatment but presents no new clinical findings, highlighting their potential benefits and limitations in regenerative medicine.

research Immunological Challenges Associated With Artificial Skin Grafts: Available Solutions and Stem Cells in Future Design of Synthetic Skin

105 citations , December 2017 in “Journal of Biological Engineering”

This review discusses the challenges of skin graft acceptance and examines current strategies and alternatives for full-thickness skin replacement and repair, noting that immunological rejection remains a significant hurdle.

research Morphogenesis of Chimeric Hair Follicles in Engineered Skin Substitutes With Human Keratinocytes and Murine Dermal Papilla Cells

46 citations , August 2012 in “Experimental Dermatology”

In this study, engineered skin substitutes containing murine dermal papilla cells developed hair follicle-like structures when grafted onto mice, suggesting a model for generating chimeric hair.