A Concise Review on Tissue Engineered Artificial Skin Grafts for Chronic Wound Treatment: Can We Reconstruct Functional Skin Tissue In Vitro?

The review discussed the advancements and challenges in developing tissue-engineered artificial skin grafts for chronic wound treatment, emphasizing the potential of various biomaterials and stem cell technologies to reconstruct functional skin tissue in vitro. Key findings included the beneficial effects of curcumin on wound healing, the role of neurotensin-loaded collagen dressings in reducing inflammation, and the promising results of stem cell therapies. Despite significant progress, the review concluded that achieving fully functional skin tissue remained a complex challenge due to issues like vascularization, integration with host tissue, and the replication of skin appendages such as hair follicles and sweat glands. Further research was needed to optimize these technologies for clinical applications.