TLDR Creating fully functional artificial skin for chronic wounds is still very challenging.
The review discussed the advancements and challenges in developing tissue-engineered artificial skin grafts for chronic wound treatment, emphasizing the potential of various biomaterials and stem cell technologies to reconstruct functional skin tissue in vitro. Key findings included the beneficial effects of curcumin on wound healing, the role of neurotensin-loaded collagen dressings in reducing inflammation, and the promising results of stem cell therapies. Despite significant progress, the review concluded that achieving fully functional skin tissue remained a complex challenge due to issues like vascularization, integration with host tissue, and the replication of skin appendages such as hair follicles and sweat glands. Further research was needed to optimize these technologies for clinical applications.
71 citations,
February 2020 in “Journal of Translational Medicine” Progress has been made in skin and nerve regeneration, but more research is needed to improve methods and ensure safety.
43 citations,
July 2019 in “Stem Cells International” Advancements in creating skin grafts with biomaterials and stem cells are promising, but more research is needed for clinical application.
184 citations,
December 2018 in “Nature Communications” Researchers created human hair follicles using a new method that could help treat hair loss.
45 citations,
August 2018 in “Stem Cells International” Stem cells, especially from fat tissue and Wharton's jelly, can potentially regenerate hair follicles and treat hair loss, but more research is needed to perfect the treatment.
5 citations,
April 2021 in “Biomedicines” The engineered skin substitute helped grow skin with hair on mice.
2 citations,
May 2023 in “Frontiers in Bioengineering and Biotechnology” The document concludes that more research is needed on making and understanding biomaterial scaffolds for wound healing.
1 citations,
December 2023 in “Biomaterials advances” Sponges made of soy protein and β-chitin with human cells from hair or fat can speed up healing of chronic wounds.
43 citations,
July 2019 in “Stem Cells International” Advancements in creating skin grafts with biomaterials and stem cells are promising, but more research is needed for clinical application.
January 2012 in “Elsevier eBooks” New treatments for skin and hair repair show promise, but further improvements are needed.
