TLDR Sponges made of soy protein and β-chitin with human cells from hair or fat can speed up healing of chronic wounds.
The study explored the use of mesenchymal stromal cells (MSCs) from hair follicles and adipose tissue, combined with sponge-like scaffolds (SLS) made of soy protein and β-chitin, to enhance healing in chronic wounds. Both hair follicle and adipose tissue derived MSCs, when paired with SLS, showed pro-regenerative and protective effects, reducing wound healing time in vivo. The combined therapy also resulted in a more functional and native-like healed skin. In vitro, both types of MSC-SLS increased cell migration and wound closure, and enhanced blood vessel formation. In vivo tests on 32 male db/db mice showed improved wound healing with both types of MSC-SLS treatments. The study concluded that this combination of cells and biomaterials could be a promising therapy for chronic wound healing.
22 citations,
April 2022 in “Stem cell research & therapy” Hair follicle-derived extracellular vesicles may help heal chronic wounds as effectively as those from adipose tissue.
7 citations,
January 2022 in “Biomedicines” Cells from the lower part of hair follicles are a promising, less invasive option for immune system therapies.
147 citations,
November 2020 in “International Journal of Molecular Sciences” Keratinocytes help heal skin wounds by interacting with immune cells and producing substances that kill pathogens.
133 citations,
July 2020 in “Cells” Creating fully functional artificial skin for chronic wounds is still very challenging.
6 citations,
April 2020 in “Applied sciences” Hair growth medium helps heal wounds and regrow hair in mice.
220 citations,
March 2020 in “Advanced functional materials” Biomaterials with MSC-derived substances could improve tissue repair and have advantages over direct cell therapy.
520 citations,
February 2001 in “Journal of Clinical Investigation” VEGF helps hair grow and determines follicle size by increasing blood vessel growth.
4 citations,
June 2022 in “BioMed Research International” Using mesenchymal stem cells or their exosomes is safe for COVID-19 patients and helps improve lung healing and oxygen levels.
96 citations,
December 2018 in “Immunity” Targeting TGFβ can improve skin immunity in older people.
December 2023 in “Frontiers in endocrinology” Excess androgens may cause PCOS, not just be a symptom.
October 2023 in “Frontiers in endocrinology” Effective PCOS treatments require targeting specific signaling pathways.
7 citations,
June 2021 in “Trends in Food Science and Technology” Western diet may cause male pattern baldness; low glycemic diet with magnesium could help.
