A State-Of-The-Art Overview On (Epi)Genomics And Personalized Skin Rejuvenating Strategies

December 2025 in “ Pharmaceutics ”

Roxana-Georgiana Tauser, Ioana Vasincu, Andreea-Teodora Iacob, Maria Apotrosoaei, Bianca-Ștefania Profire, Florentina Lupaşcu, Oana-Maria Ionescu, Lenuţa Profire

epigenomics genomics personalized medicine DNA methylation stem cell therapy senolytics Dasatinib Quercetin skin aging artificial intelligence machine learning genetic reprogramming HOTAIR modulators tretinoin laser therapies AI retinoic acid Retin-A

From the encyclopedia

Quercetin →

Tretinoin →

the gold standard retinoid in dermatology that's also helpful for hair regrowth alongside Minoxidil

retinoic acid →

Studysummary This review highlights new perspectives in genomics and epigenomics for skin rejuvenation, comparing innovative strategies like senolytics and DNA repair modulators with classical treatments, and emphasizing the importance of tailoring therapies using individual genomic profiles for personalized anti-ageing approaches.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The document provides a comprehensive overview of advancements in (epi)genomics and personalized strategies for skin rejuvenation, emphasizing the potential of personalized medicine by leveraging genomic and epigenomic data. It discusses various molecular and cellular mechanisms, such as DNA methylation, stem cell therapy, and senolytics like Dasatinib and Quercetin, in combating skin aging. The review highlights the integration of artificial intelligence and machine learning in predicting skin aging and tailoring treatments. It also addresses the challenges in translating genetic reprogramming into clinical applications, the role of HOTAIR modulators, and the potential widespread adoption of these strategies. While classical treatments like tretinoin and laser therapies are well-established, emerging (epi)genomic strategies show promise but require further research and development due to limited human data and regulatory challenges.

View this study on mdpi.com →

Discuss this study in the Community →

Research cited in this study

9 / 9 results

research Use of Exosomes for Cosmetic Applications

January 2025 in “Cosmetics”

In this study, a systematic review highlighted the potential of exosomes in cosmetics and regenerative medicine for improving skin rejuvenation and addressing aging, while also pointing out existing challenges such as regulatory hurdles and the need for more clinical validation.

research Regenerative Cosmetics: Skin Tissue Engineering for Anti-Aging, Repair, and Hair Restoration

1 citations , June 2024

This review explores the potential of regenerative cosmetics, utilizing engineered skin tissues, to address aging, damage, and hair loss by enhancing collagen production, reducing wrinkles, and regenerating hair follicles, highlighting a transformative approach in dermocosmetics.

research Dermatologic Manifestations of Mitochondrial Dysfunction: A Review of the Literature

March 2024 in “International journal of molecular sciences”

This review summarizes current literature associating mitochondrial dysfunction with dermatologic issues like skin aging, hair loss, and poor wound healing, noting potential benefits in targeting mitochondrial components for treatments.

research Exosomal MicroRNA-Based Therapies for Skin Diseases

December 2023 in “Regenerative therapy”

In this review, the authors reported that exosomal miRNA-based therapies showed promising therapeutic effects on nine skin diseases in animal models, with enhanced outcomes observed when using miRNA-overexpressing exosomes compared to natural ones; however, no comparisons to standard treatments were available.

research LncRNA-miRNA-mRNA Regulatory Networks in Skin Aging and Therapeutic Potentials

3 citations , October 2023 in “Frontiers in physiology”

This study reviewed competing endogenous RNA networks related to skin aging and wound healing, finding mechanisms like UVB-induced senescence and photoaging, as well as potential therapeutic targets for improving skin health and recovery.

research Enhancing Skin Anti-Aging Through Healthy Lifestyle Factors

1 citations , September 2023

This study's overview highlights that lifestyle factors like nutrition, sleep, physical activity, and social interactions can significantly enhance skin health with aging. The authors suggest social media campaigns promoting these habits could potentially improve skin well-being in the future.

Innovations in Skin and Soft Tissue Aging: A Systematic Literature Review and Market Analysis of Therapeutics and Associated Outcomes

research Innovations in Skin and Soft Tissue Aging: A Systematic Literature Review and Market Analysis of Therapeutics and Associated Outcomes

17 citations , May 2023 in “Aesthetic Plastic Surgery”

This review found that among emerging technologies for skin anti-aging, stem cell therapies using recipient chimerism might be more beneficial than CRISPR-Cas9 and other current innovations, though further studies on safety and efficacy are needed.

research Autologous Cell Therapy for Aged Human Skin: A Randomized, Placebo-Controlled, Phase I Study

6 citations , September 2019 in “Skin pharmacology and physiology”

This study found that RCS-01 cell therapy for aged skin was well tolerated and associated with increased gene expression related to extracellular matrix homeostasis, suggesting potential skin improvement.

research Targeting Oxidative Stress and Mitochondrial Dysfunction in the Treatment of Impaired Wound Healing: A Systematic Review

280 citations , July 2018 in “Antioxidants”

This review discusses the role of reactive oxygen species in wound healing, highlighting potential strategies like mitochondrial-targeted antioxidants for managing non-healing chronic wounds, and reports no new clinical results.