Immunological Control of Skin Development: From Homeostasis to Developmental Pathologies

    November 2025 in “ Frontiers in Immunology ”
    Yutong Wei, Jing Gu, Zifan Zhao, Bin Gu
    TLDR Immune cells are crucial for normal skin development and their dysfunction can cause skin disorders.
    The document discusses the role of immune cells in skin development, highlighting their involvement in processes like vascular formation, epidermal stratification, and hair follicle morphogenesis. It integrates findings from mouse models and human clinical observations to show how immune cells such as macrophages, Langerhans cells, dendritic cells, mast cells, and innate lymphoid cells contribute to normal skin development. The review also examines how immune cell dysfunction can lead to skin disorders, including congenital abnormalities, autoimmune diseases, and fibrosis. The insights gained provide a basis for developing therapies aimed at modulating immune pathways for skin regeneration, with future research focusing on advanced technologies to better understand immune-tissue interactions.
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