3D Bioprinting of Prefabricated Artificial Skin with Multicomponent Hydrogel for Skin and Hair Follicle Regeneration

    February 2025 in “ Theranostics ”
    Xiaoxiao Ma, Xiaohui Zhu, Sheng Lv, Chunyan Yang, Zihao Wang, M. Liao, Bohao Zhou, Yiming Zhang, Shiyu Sun, Ping Chen, Liu Z, Haiyan Chen
    Image of study
    TLDR 3D bioprinting with special hydrogels can create artificial skin that heals wounds and regrows hair in mice.
    This study investigates the use of 3D bioprinting with multicomponent hydrogels, specifically a combination of gelatin methacrylate (GelMA) and hyaluronic acid methacrylate (HAMA), to create artificial skin capable of regenerating skin and hair follicles. The research involved using epidermal stem cells (Epi-SCs) and skin-derived precursors (SKPs) within the hydrogel, which demonstrated excellent printability, biocompatibility, and mechanical properties. When tested in vivo on mice, the artificial skin facilitated complete wound healing and regeneration of functional tissues, including hair follicles, within 4 weeks. This approach shows significant potential for clinical applications in skin and hair follicle regeneration, although challenges remain in scaling up stem cell cultures and verifying efficacy with human cells.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 38 results

      community Am I taking out too much foam for a dose? Rogaine Minoxidil

      in Minoxidil 2 years ago
      This conversation discusses the topical application of Minoxidil, with various users providing advice on how to accurately measure a dose and keep it from melting too quickly. Others have shared their experiences using oral finasteride for hair loss treatments.

      community Scalp Micropigmentation while having hair

      in Treatment  6 upvotes 3 years ago
      User discusses scalp micropigmentation for denser hair appearance and its benefits compared to lifelong treatments. Special ink is used, which can fade and blur over time but can be topped up.

      community Surprisingly thorough study on He-Shou-Wu/Fo Ti

      in Research/Science  14 upvotes 2 years ago
      He Shou Wu (Fo Ti) extract was found to prolong the hair growth phase, inhibit 5-alpha-reductase (like finasteride), reduce androgen receptors, and increase growth factors, potentially outperforming minoxidil in recovering hair follicle size after DHT exposure. Two compounds, emodin and TSG, are identified as responsible for these effects and warrant further investigation.

      community Has anyone tried this new peptide ghk-cu?

      in Treatment  3 upvotes 4 days ago
      People are discussing the use of the peptide GHK-Cu for hair and skin, with mixed results. Some users have tried it alongside other treatments like adenosine and melatonin, but have not seen significant improvements, and one user stopped due to cost.

    Similar Research

    5 / 1000+ results