Head And Neck 3D Bioprinting: A Review On Recent Advancements In Soft Tissue 3D Bioprinting And Medical Applications

June 2025 in “ Journal of Functional Biomaterials ”

Iosif-Aliodor Timofticiuc, Ana Căruntu, Christiana Diana Maria Dragosloveanu, Andreea-Elena Scheau, Ioana Anca Bădărău, Argyrios Periferakis, Şerban Dragosloveanu, Andreea Cristiana Didilescu, Constantin Căruntu, Cristian Scheau

3D bioprinting soft tissue sebaceous glands hair follicles bioinks biocompatibility vascularization

Studysummary This study explored recent advancements in 3D bioprinting for head and neck defects, highlighting how bioinks and scaffolds may improve treatment customization and functionality by mimicking native tissue features. The research also examined challenges like biocompatibility and regulatory requirements on the path to clinical use.

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The review highlights recent advancements in 3D bioprinting for head and neck soft tissue applications, emphasizing its potential to improve traditional treatments by creating complex tissue structures with integrated sebaceous glands and hair follicles. It discusses the use of bioinks and various bioprinting techniques to enhance anatomical precision and biofunctionality, while addressing challenges such as biocompatibility, immune response, and vascularization. The review underscores the potential of 3D bioprinting to reduce reliance on human donors and improve patient outcomes, although further research is needed to overcome mechanical, metabolic, and integration challenges for clinical applications.

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research 3D Printing of Skin Equivalents with Hair Follicle Structures and Epidermal-Papillary-Dermal Layers Using Gelatin/Hyaluronic Acid Hydrogels

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