Incorporation of Hair Follicles in 3D Bioprinted Models of Human Skin

October 2023 in “ Science Advances ”

Carolina Motter Catarino, Desirée Cigaran Schuck, Lexi Dechiario, Pankaj Karande

hair follicles 3D bioprinting dermal papilla cells fibroblasts engineered skin tissues regenerative medicine

TLDR 3D bioprinting can now create skin with hair-like structures for medical use.

The study demonstrates the successful incorporation of hair follicle-like structures into engineered skin tissues using 3D bioprinting. By precisely printing spheroids composed of dermal papilla cells and human umbilical vein cells within a pregelled dermal layer containing fibroblasts, the engineered tissue developed structures that closely resemble native skin. This advancement in creating more complex and realistic skin models holds significant potential for applications in regenerative medicine, particularly as grafts and in testing the safety of chemical compounds.

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