Incorporation of Hair Follicles in 3D Bioprinted Models of Human Skin

This study successfully demonstrates the incorporation of hair follicle-like structures into 3D bioprinted models of human skin using a combination of dermal papilla cells (DPCs), human umbilical vein endothelial cells (HUVECs), human epidermal keratinocytes (HEKs), and human epidermal melanocytes (HEMs). The bioprinted skin models mimic the morphology and composition of native skin, showing potential for applications in regenerative medicine, such as grafts and chemical safety testing. The study highlights the high cell viability achieved and the formation of well-organized structures resembling human dermal papilla. Despite challenges in scalability and reproducibility, this approach marks a significant advancement in creating complex skin models with hair follicle structures.