Reconstructed Human Skin Shows Epidermal Invagination Towards Integrated Neopapillae Indicating Early Hair Follicle Formation In Vitro

May 2020 in “ Journal of Tissue Engineering and Regenerative Medicine ”

Irit Vahav, Lenie J. van den Broek, Maria Thon, Hanneke N. Monsuur, Sander W. Spiekstra, Beren Ataç, Rik J. Scheper, Roland Lauster, G Lindner, Uwe Marx, Susan Gibbs

TLDR The experiment showed that human skin grown in the lab started to form early hair structures when special cell clusters were added.

The study from May 3, 2020, investigated the initiation of hair follicle formation in vitro by integrating neopapillae spheroids, which are condensed dermal papilla cells, into reconstructed human skin (RhS). The neopapillae spheroids were found to promote epidermal downgrowth and the early stages of hair follicle morphogenesis by expressing key genes and secreting factors that regulate hair development, including the keratinocyte chemoattractant cytokine CXCL1. The study, which involved three independent experiments with cells from different donors, concluded that the RhS model containing neopapillae could demonstrate the initial steps towards hair follicle formation in vitro, providing a valuable tool for further research in hair biology and regenerative medicine. The specific number of participants or samples was not mentioned in the summary.

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