184 citations
,
December 2018 in “Nature Communications” Researchers created human hair follicles using a new method that could help treat hair loss.
85 citations
,
January 2018 in “Cell stem cell” Different signals work together to change gene activity and guide hair follicle stem cells to become specific cell types.
31 citations
,
October 2017 in “Dermatologic Surgery” Hair transplants look natural, but the best method is debated, and PRP shows promise for hair regrowth.
223 citations
,
January 2014 in “International Journal of Molecular Sciences” The conclusion is that proper signaling is crucial for hair growth and development, and errors can lead to cancer or hair loss.
256 citations
,
October 2013 in “Proceedings of the National Academy of Sciences of the United States of America” Growing human skin cells in a 3D environment can stimulate new hair growth.
208 citations
,
January 2013 in “Lab on a Chip” The Multi-Organ-Chip improves the growth and quality of skin and hair in the lab, potentially replacing animal testing.
45 citations
,
January 2012 in “Experimental Dermatology” Human hair follicles switch between active and resting phases unpredictably.
44 citations
,
January 2011 in “Journal of biotechnology” Scientists recreated human hair follicles in the lab that can grow hair.
759 citations
,
February 2009 in “Current Biology” Hair follicles are complex, dynamic mini-organs that help us understand cell growth, death, migration, and differentiation, as well as tissue regeneration and tumor biology.
479 citations
,
January 2005 in “BioEssays” Hair follicle development is controlled by interactions between skin tissues and specific molecular signals.
277 citations
,
June 2003 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings” Epithelial-mesenchymal interactions control hair growth cycles through specific molecular signals.
78 citations
,
August 2002 in “Experimental Dermatology” Researchers developed a quick and easy way to get and grow cells from the base of human hair follicles.
67 citations
,
July 2000 in “Proceedings of the National Academy of Sciences” The model accurately simulates human hair growth and hair loss patterns.
990 citations
,
October 1999 in “Development” The study investigated the role of activated LEF/TCF transcription factor complexes in hair follicle development and differentiation using engineered mice with a β-galactosidase gene (TOPGAL) under a LEF/TCF and β-catenin inducible promoter. It was found that TOPGAL expression was stimulated by stabilized β-catenin and required LEF1/TCF3 in the skin. During embryogenesis, TOPGAL activation was transient in certain LEF1-positive cells, and while LEF1 was expressed in proliferative matrix cells, TOPGAL was co-induced with hair-specific keratin genes in hair shaft precursor cells. LEF1 and TOPGAL expression ceased during catagen and telogen but reappeared at the start of the postnatal hair cycle. TCF3 was expressed in postnatal outer root sheath and putative follicle stem cells, with TOPGAL activation dependent on β-catenin stabilization. The findings highlighted that LEF1/TCF3 was necessary but not sufficient for TOPGAL activation, indicating the presence of additional regulatory factors in the skin and underscoring the critical role of activated LEF/TCF complexes in hair development and cycling.
1113 citations
,
August 1999 in “The New England Journal of Medicine” Hair follicle biology advancements may lead to better hair growth disorder treatments.
72 citations
,
December 1996 in “Journal of Investigative Dermatology” Human hair follicles can regenerate after removal, but with low success rate.
28 citations
,
July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology”
