Skin And Hair On-A-Chip: In Vitro Skin Models Versus Ex Vivo Tissue Maintenance With Dynamic Perfusion

January 2013 in “ Lab on a Chip ”

Beren Ataç, Ilka Wagner, Reyk Horland, Roland Lauster, Uwe Marx, A. G. Tonevitsky, Reza P. Azar, G Lindner

Multi-Organ-Chip MOC in vitro skin models ex vivo tissue maintenance dynamic perfusion skin equivalents hair follicles static cultures hair shaft elongation regression phase of hair growth dermal toxicity assays skin models tissue maintenance perfusion skin tissue hair growth toxicity testing

TLDR The Multi-Organ-Chip improves the growth and quality of skin and hair in the lab, potentially replacing animal testing.

In 2013, researchers introduced a dynamic perfusion system called the Multi-Organ-Chip (MOC) to improve the culture of skin and hair follicle tissues in vitro. The MOC system was found to enhance the viability and structural integrity of skin equivalents and hair follicles compared to static cultures. It allowed for prolonged culture periods, maintained key tissue markers, reduced cell death, and supported hair shaft elongation, indicating a delay in the regression phase of hair growth. This platform could potentially replace animal studies for dermal toxicity assays and improve the testing of substances on skin models. The study was funded by the German Federal Ministry of Education and Research and the Russian Ministry for Science.

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research Skin And Hair On-A-Chip: In Vitro Skin Models Versus Ex Vivo Tissue Maintenance With Dynamic Perfusion

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