Skin And Hair On-A-Chip: In Vitro Skin Models Versus Ex Vivo Tissue Maintenance With Dynamic Perfusion

January 2013 in “ Lab on a Chip ”

Beren Ataç, Ilka Wagner, Reyk Horland … G Lindner

Multi-Organ-Chip MOC in vitro skin models ex vivo tissue maintenance dynamic perfusion skin equivalents hair follicles static cultures hair shaft elongation regression phase of hair growth dermal toxicity assays skin models tissue maintenance perfusion skin tissue hair growth toxicity testing

Studysummary The researchers described a chip-based bioreactor platform for dynamic perfusion, which may enhance in vitro skin models by introducing mechanical shear stress and extending culture periods.

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Research cited in this study 5

Adipocyte Lineage Cells Contribute to the Skin Stem Cell Niche to Drive Hair Cycling Cell · 2011
De Novo Formation and Ultra-Structural Characterization of a Fiber-Producing Human Hair Follicle Equivalent In Vitro Journal of biotechnology · 2011
Follicular Transport Route: Research Progress and Future Perspectives European journal of pharmaceutics and biopharmaceutics · 2009
Hair Follicle Stem Cells: Walking the Maze European Journal of Cell Biology · 2007
Human Hair Growth In Vitro Journal of Cell Science · 1990

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Skin And Hair On-A-Chip: In Vitro Skin Models Versus Ex Vivo Tissue Maintenance With Dynamic Perfusion Lab on a Chip · 2013