Keratin K15 as a Biomarker of Epidermal Stem Cells

    September 2013 in “ International Journal of Molecular Sciences ”
    Amrita Bose, Muy-Teck Teh, Ian C. Mackenzie, Ahmad Waseem
    Studysummary This review evaluates existing research on Keratin 15 to assess its validity as a marker for epidermal stem cells, reporting no new results.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on mdpi.com →
    Discuss this study in the Community →

    Research cited in this study 18

    1. Two Mechanisms Regulate Keratin K15 Expression in Keratinocytes: Role of PKC/AP-1 and FOXM1 Mediated Signaling PloS one · 2012
    2. 25 Years of Epidermal Stem Cell Research Journal of Investigative Dermatology · 2012
    3. Reassessing K15 as an Epidermal Stem Cell Marker Stem Cell Reviews and Reports · 2011
    4. Bald Scalp in Men with Androgenetic Alopecia Retains Hair Follicle Stem Cells but Lacks CD200-Rich and CD34-Positive Hair Follicle Progenitor Cells Journal of Clinical Investigation · 2011
    5. Epidermolysis Bullosa Simplex: A Paradigm for Disorders of Tissue Fragility ˜The œJournal of clinical investigation/˜The œjournal of clinical investigation · 2009
    6. Epidermal Stem Cells: Practical Perspectives and Potential Uses British Journal of Dermatology · 2009
    7. Lgr5 Marks Cycling, Yet Long-Lived, Hair Follicle Stem Cells Nature Genetics · 2008
    8. Markers to Evaluate the Quality and Self-Renewing Potential of Engineered Human Skin Substitutes In Vitro and After Transplantation ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2008
    9. The Human Keratins: Biology And Pathology Histochemistry and Cell Biology · 2008
    10. Characterization and Isolation of Stem Cell-Enriched Human Hair Follicle Bulge Cells ˜The œJournal of clinical investigation/˜The œjournal of clinical investigation · 2005
    11. Location and Phenotype of Human Adult Keratinocyte Stem Cells of the Skin Differentiation · 2004
    12. The Keratins and Their Disorders American journal of medical genetics. Part C, Seminars in medical genetics · 2004
    13. Keratin 15 Promoter Targets Putative Epithelial Stem Cells in the Hair Follicle Bulge Journal of Investigative Dermatology · 2003
    14. Enrichment for Living Murine Keratinocytes from the Hair Follicle Bulge with the Cell Surface Marker CD34 Journal of Investigative Dermatology · 2003
    15. Cytokeratin 15 Expression in Trichoepitheliomas and a Subset of Basal Cell Carcinomas Suggests They Originate from Hair Follicle Stem Cells Journal of Cutaneous Pathology · 1999
    16. Keratin 15 Expression in Stratified Epithelia: Downregulation in Activated Keratinocytes Journal of Investigative Dermatology · 1999
    17. Expression of the Intermediate Filament Keratin Gene K15 in the Basal Cell Layers of Epithelia and the Hair Follicle Experimental Cell Research · 1998
    18. Keratin 19 as a Biochemical Marker of Skin Stem Cells In Vivo and In Vitro: Localization and Variation with Age and Culture Stage Journal of Cell Science · 1996

    Related research 1

    1. Multi-Potentiality of a New Immortalized Epithelial Stem Cell Line Derived from Human Hair Follicles In vitro cellular & developmental biology. Animal · 2008