The Human Keratins: Biology And Pathology

    May 2008 in “ Histochemistry and Cell Biology ”
    Roland Moll, Markus Divo, Lutz Langbein
    Studysummary This review summarizes the cell type distribution and functional significance of human keratins, emphasizing their roles in tumor diagnosis and potential clinical applications, and reports no new clinical findings.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 43

    1. Hair Follicle-Specific Keratins And Their Diseases Experimental cell research · 2007
    2. Novel Type I Hair Keratins K39 And K40 Are The Last To Be Expressed In Differentiation Of The Hair: Completion Of The Human Hair Keratin Catalog Journal of Investigative Dermatology · 2007
    3. Keratin Expression Provides Novel Insight Into the Morphogenesis and Function of the Companion Layer in Hair Follicles Journal of Investigative Dermatology · 2006
    4. K25 (K25irs1), K26 (K25irs2), K27 (K25irs3), And K28 (K25irs4) Represent The Type I Inner Root Sheath Keratins Of The Human Hair Follicle Journal of Investigative Dermatology · 2006
    5. Keratin 17 Modulates Hair Follicle Cycling in a TNFα-Dependent Fashion Genes & Development · 2006
    6. A Mutation in the Hair Matrix and Cuticle Keratin KRTHB5 Gene Causes Ectodermal Dysplasia of Hair and Nail Type Journal of Medical Genetics · 2006
    7. Human Hair Keratin-Associated Proteins International review of cytology · 2006
    8. Expression Patterns of Hair and Epithelial Keratins and Transcription Factors HOXC13, LEF1, and β-Catenin in a Malignant Pilomatricoma: A Histological and Immunohistochemical Study Journal of Cutaneous Pathology · 2005
    9. Characterization of New Members of the Human Type II Keratin Gene Family and a General Evaluation of the Keratin Gene Domain on Chromosome 12q13.13 Journal of Investigative Dermatology · 2005
    10. Keratins of the Human Hair Follicle International review of cytology · 2005
    11. The Human Type I Keratin Gene Family: Characterization of New Hair Follicle Specific Members and Evaluation of the Chromosome 17q21.2 Gene Domain Differentiation · 2004
    12. Expression of Hair Keratins in the Adult Nail Unit: An Immunohistochemical Analysis of Onychogenesis in the Proximal Nail Fold, Matrix, and Nail Bed British Journal of Dermatology · 2004
    13. On The Regulation Of Hair Keratin Expression: Lessons From Studies In Pilomatricomas Journal of Investigative Dermatology · 2004
    14. An Unusual Ala12Thr Polymorphism in the 1A Alpha-Helical Segment of the Companion Layer-Specific Keratin K6hf: Evidence for a Risk Factor in the Etiology of the Common Hair Disorder Pseudofolliculitis Barbae Journal of Investigative Dermatology · 2004
    15. Hair Keratins And Hair Follicle-Specific Epithelial Keratins Methods in cell biology · 2004
    16. Type II Epithelial Keratin 6hf (K6hf) Is Expressed in the Companion Layer, Matrix, and Medulla in Anagen-Stage Hair Follicles Journal of Investigative Dermatology · 2003
    17. K6irs1, K6irs2, K6irs3, And K6irs4 Represent The Inner-Root-Sheath-Specific Type II Epithelial Keratins Of The Human Hair Follicle Journal of Investigative Dermatology · 2003
    18. Cloning of Human, Murine, and Marsupial Keratin 7 and a Survey of K7 Expression in the Mouse Biochemical and Biophysical Research Communications · 2002
    19. Keratin 17 Null Mice Exhibit Age- And Strain-Dependent Alopecia Genes & Development · 2002
    20. A Novel Epithelial Keratin, hK6irs1, Is Expressed Differentially in All Layers of the Inner Root Sheath, Including Specialized Huxley Cells of the Human Hair Follicle Journal of Investigative Dermatology · 2002
    21. Is Loose Anagen Hair Syndrome a Keratin Disorder? Archives of Dermatology · 2002
    22. Cytokeratins as Markers of Follicular Differentiation American Journal of Dermatopathology · 2001
    23. The Catalog of Human Hair Keratins Journal of Biological Chemistry · 2001
    24. Discovery of a Novel Murine Keratin 6 (K6) Isoform Explains the Absence of Hair and Nail Defects in Mice Deficient for K6a and K6b The Journal of Cell Biology · 2001
    25. Expression of Type I Hair Keratins in Follicular Tumors British Journal of Dermatology · 2001
    26. Delayed Wound Healing in Keratin 6a Knockout Mice Molecular and Cellular Biology · 2000
    27. Keratin 17 Expression in the Hard Epithelial Context of the Hair and Nail, and Its Relevance for the Pachyonychia Congenita Phenotype Journal of Investigative Dermatology · 2000
    28. Expression of the Hair Stem Cell-Specific Keratin 15 in Pilar Tumors of the Skin PubMed · 1999
    29. The Catalog of Human Hair Keratins Journal of biological chemistry/˜The œJournal of biological chemistry · 1999
    30. Cytokeratin 15 Expression in Trichoepitheliomas and a Subset of Basal Cell Carcinomas Suggests They Originate from Hair Follicle Stem Cells Journal of Cutaneous Pathology · 1999
    31. Keratin 15 Expression in Stratified Epithelia: Downregulation in Activated Keratinocytes Journal of Investigative Dermatology · 1999
    32. A Novel Human Type II Cytokeratin, K6hf, Specifically Expressed in the Companion Layer of the Hair Follicle ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1998
    33. Mutations in the Hair Cortex Keratin HHB6 Cause the Inherited Hair Disease Monilethrix Nature Genetics · 1997
    34. Expression Pattern of Human Hair Keratin Basic 1 (hHbl) in Hair Follicle and Pilomatricoma Experimental Dermatology · 1997
    35. Keratin 19: Predicted Amino Acid Sequence and Broad Tissue Distribution Suggest It Evolved from Keratinocyte Keratins Journal of Investigative Dermatology · 1989
    36. Patterns of Expression of Trichocytic and Epithelial Cytokeratins in Mammalian Tissues Differentiation · 1988
    37. Patterns of Expression of Trichocytic and Epithelial Cytokeratins in Mammalian Tissues II: Concomitant and Mutually Exclusive Synthesis of Trichocytic and Epithelial Cytokeratins in Diverse Human and Bovine Tissues (Hair Follicle, Nail Bed and Matrix, Lingual Papilla, Thymic Reticulum) Differentiation · 1988
    38. Concerted Gene Duplications in the Two Keratin Gene Families Journal of Molecular Evolution · 1988
    39. Patterns of Expression of Trichocytic and Epithelial Cytokeratins in Mammalian Tissues: Human and Bovine Hair Follicles Differentiation · 1988
    40. Differential Expression of Keratin 19 in Normal Human Epithelial Tissues Revealed by Monospecific Monoclonal Antibodies The Histochemical Journal · 1986
    41. The Complement of Native Alpha-Keratin Polypeptides of Hair-Forming Cells: A Subset of Eight Polypeptides That Differ from Epithelial Cytokeratins Differentiation · 1986
    42. Hair Keratin: Composition, Structure and Biogenesis 1986
    43. Different Keratin Polypeptides in Epidermis and Other Epithelia of Human Skin: A Specific Cytokeratin of Molecular Weight 46,000 in Epithelia of the Pilosebaceous Tract and Basal Cell Epitheliomas The Journal of Cell Biology · 1982